ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1977.tb01638.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1977.tb01639.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The accepted histological categories of chronic hepatitis are chronic persistent hepatitis (CPH) and chronic active or aggressive hepatitis (CAH). A third form, chronic lobular hepatitis (CLH), encompasses those cases in which the lesion is predominantly within the lobules and in which portal and periportal inflammation are mild, CLH has many synonyms. International agreement on a reproducible and rational nomenclature of chronic hepatitis is still far from complete. CPH is characterized by portal inflammation. Histological definition is simple, but there are diagnostic pitfalls. The category may need subdivision on the basis of immunological studies. CAH should be regarded as a complex rather than a single disease, and it is important to specify the aetiology and pathological components in each instance. The concept of CAH must be altered to incorporate the lesion bridging hepatic necrosis (BHN). Piecemeal necrosis, accompanied by inflammatory infiltration, is considered to be the most important of the various pathogenetic factors in CAH, but BHN probably plays a significant part in accelerating the development of cirrhosis. An excessive portal and periportal inflammatory reaction with or without BHN, in a liver biopsy taken during the course of an acute hepatitis, helps to predict a possible chronic course.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1977.tb01640.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Colonization of mammary cancers by melanocytes with attendant pigmentation of cancer cells by melanin occurs in most cases of breast cancer in which the dermal‐epidermal interface is reached by the tumour cells. There is evidence to suggest that the mammary cancer may become colonized at the expense of the epidermis, which is focally depleted of melanocytes. Melanocytes can even be found in groups of tumour cells within lymphatics. Colonization and pigmentation of breast cancer is usually only easily detected by selective staining methods. In very rare cases it can be gross and easily detectable in routine stains. The implications of this migratory phenomenon are discussed in terms of the biology of the melanocyt

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1977.tb01641.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Two examples are reported of eosinophilic granuloma presenting as lymphadenopathy and being apparently confined to lymph nodes. The affected nodes were characterized by a striking sinus histiocytosis, a heavy infiltration with mature eosinophils and retention of normal lymphoid follicles. The differential diagnosis of this histological picture is discussed and the prognosis considered.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1977.tb01642.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

In a series of 250 renal biopsies (transplants excluded) the diagnosis of membranous glomerulonephritis was made in 22. This was done on light microscopy in 17, while the addition of immunofluorescence enabled the diagnosis to be made in a further five. Electron microscopy confirmed the diagnosis in all cases. Immunoperoxidase studies emphasized the basement membrane distribution of the deposits of immunoglobulin and the relative sparing of the mesangium. They showed at an ultrastructural level the presence of IgG in the deposits.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1977.tb01643.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The histology of 125 cases of primary gastrointestinal lymphomas arising in the stomach and small and large intestine has been reviewed. The material was gathered from the Bland‐Sutton Institute of Pathology at the Middlesex Hospital and from the Westminster Hospital. Of the initial total of 143 cases diagnosed, 18 were rejected. Of the acceptable 125 cases, 51 lymphomas were arising in stomach, 53 in the small intestine and 21 in the large intestine including rectum. Excluding the four children in the series, ages ranged from 18 to 82 and were fairly evenly distributed across the decades. There was no significant sex difference in the Middlesex Hospital cases but in the Westminster Hospital series the male to female ratio was approximately 2.6 to 1. One significant finding to emerge from this histological survey, and which forms the basis of this communication, is the proportion of lymphomas considered to be predominantly of plasma cell type. These plasma cell tumours, or extramedullary plasmacytomas, accounted for 49 out of the 125 cases (39%) of gastrointestinal lymphomas. They were less common in stomach and most common in the intestine, the majority occurring in the ileocaecal region. Conversely, Hodgkin's disease, in contrast to some series, was not encountered. Of the non‐Hodgkin's lymphomas, grade I tumours were uncommon and true histiocytic lymphomas were distinctly rare. The high incidence of plasma cell tumours in our series is in keeping with the morphological findings of a previous study carried out in patients with alpha‐chain disease and in a small series of primary gastrointestinal lymp

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1977.tb01644.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Eight cases of the rare undifferentiated carcinoma of the large intestine are described. The histological distinction between undifferentiated and poorly differentiated colonic adenocarcinoma and malignant carcinoid is discussed. It is concluded that undifferentiated carcinoma is a variant of adenocarcinoma which tends to grow to a large size before symptoms are produced but which nevertheless has a good prognosis when locally resectable. Five patients survived between 6 and 28 years, one is well 6 months after operation and two cases where local removal could not be achieved, died within a year.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1977.tb01645.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1977.tb01646.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY