摘要:

When tested in three experimental staphylococcal infections—acute peritonitis in mice, mouse leg edema produced by a localized infection, and dermal rabbit ear infections—lysostaphin demonstrated in vivo chemotherapeutic activity. Doses of less than 0.007 mg/kg (intraperitoneally) and 0.5 mg/kg (subcutaneously) of lysostaphin prevented death in 50% of the mice with acute staphylococcal peritonitis. A single intramuscular dose (0.15 mg/mouse) of lysostaphin suppressed the swelling produced by the injection of staphylococci into mouse legs to 50% of that produced in untreated animals. Lysostaphin (0.05% by weight) incorporated into gels and applied topically eradicated staphylococci from experimental skin lesions on the ears of rabbits. Lysostaphin was absorbed and transported by the body fluids from the point of injection to the site of the infection producing a desirable antistaphylococcal effect.

ISSN:0008-4166    

DOI:10.1139/m67-011

出版商:NRC Research Press    

年代:1967

数据来源: NRC

摘要:

The composition of the extracellular polysaccharides of 10 strains ofRhizobium melilotiwas investigated. Glucose, galactose, and glucuronic acid were found as components; their amounts, determined after hydrolysis as a percentage of the total sugars, varied from 82 to 86 for glucose, 13 to 16 for galactose, and 0.4 to 1.2 for glucuronic acid. No significant difference between the strains was found, which suggests a homogeneity of the extracellular polysaccharides ofRhizobium meliloti.

ISSN:0008-4166    

DOI:10.1139/m67-012

出版商:NRC Research Press    

年代:1967

数据来源: NRC

ISSN:0008-4166    

DOI:10.1139/m67-013

出版商:NRC Research Press    

年代:1967

数据来源: NRC

ISSN:0008-4166    

DOI:10.1139/m67-014

出版商:NRC Research Press    

年代:1967

数据来源: NRC

ISSN:0008-4166    

DOI:10.1139/m67-015

出版商:NRC Research Press    

年代:1967

数据来源: NRC

ISSN:0008-4166    

DOI:10.1139/m67-016

出版商:NRC Research Press    

年代:1967

数据来源: NRC

ISSN:0008-4166    

DOI:10.1139/m67-017

出版商:NRC Research Press    

年代:1967

数据来源: NRC