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1. |
Editorial |
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Fetal Diagnosis and Therapy,
Volume 6,
Issue 1-2,
1991,
Page 1-1
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PDF (273KB)
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ISSN:1015-3837
DOI:10.1159/000263616
出版商:S. Karger AG
年代:1991
数据来源: Karger
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2. |
Ultrasonographic Diagnosis and Perinatal Management of Fetal Abdominal Wall Defects |
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Fetal Diagnosis and Therapy,
Volume 6,
Issue 1-2,
1991,
Page 2-10
E.J. van de Geijn,
J.M.G. van Vugt,
J.E. Sollie,
H.P. van Geijn,
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摘要:
Thirty-four fetuses with ultrasonographically diagnosed abdominal wall defects are described. In 20 out of the 25 (80%) cases with omphalocele, there were associated abnormalities, mainly chromosomal defects (48%), cardiac (28%), genitourinary (20%), craniofacial (20%) and diaphragmatic anomalies (12%). In gastroschisis, associated structural anomalies occurred in 2 out of 5. The 4 cases of abdominal wall defects as a part of amniotic band syndrome were associated with multiple severe defects. No chromosomal defects were found in the group with gastroschisis and amniotic band syndrome. Intrauterine fetal death occurred in 8 cases. Sixteen pregnancies were electively aborted because of an association with an anomaly incompatible with postnatal life; 3 pregnancies were electively terminated on their parents’ own request. Two infants died shortly after birth. Seven infants were successfully treated. When level I ultrasound examination demonstrates a fetal abdominal wall defect, a detailed level II ultrasound examination is recommended to exclude associated malformations. In case of omphalocele, prenatal chromosome analysis is indicated. Delivery in a tertiary care center is recommended. A randomized prospective trial is needed to see whether cesarean section or vaginal delivery is the preferred mode of delivery for these infant
ISSN:1015-3837
DOI:10.1159/000263617
出版商:S. Karger AG
年代:1991
数据来源: Karger
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3. |
Fetal Abdominal Wall Defect: A New Complication of Vesicoamniotic Shunting |
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Fetal Diagnosis and Therapy,
Volume 6,
Issue 1-2,
1991,
Page 11-13
Alfred G. Robichaux III,
James Mandell,
Michael F. Greene,
Beryl R. Benacerraf,
Mark I. Evans,
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PDF (694KB)
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摘要:
Vesicoamniotic shunting for fetal obstructive uropathy is beneficial in selected cases. We report a new complication, fetal abdominal wall defect secondary to vesicoamniotic shunting. Placement of the shunt should be as low and as close to the fetal midline as possible in order to reduce the risk of this complication.
ISSN:1015-3837
DOI:10.1159/000263618
出版商:S. Karger AG
年代:1991
数据来源: Karger
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4. |
Contribution of Demographic and Environmental Factors to the Etiology of Gastroschisis: A Hypothesis |
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Fetal Diagnosis and Therapy,
Volume 6,
Issue 1-2,
1991,
Page 14-27
Robert A. Drongowski,
Kendall Smith, Jr.,
Arnold.G. Coran,
Michael D. Klein,
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PDF (2042KB)
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摘要:
We examined the clinical literature on congenital abdominal wall defects to confirm our impression that gastroschisis had become more common than omphalocele. We then examined the teratology literature and noted that congenital abdominal wall defects were frequently induced by teratogens. This lead us to review the antenatal history of 19 infants with gastroschisis and 54 control infants born with a congenital anomaly unrelated to gastroschisis. When compared to controls, mothers of infants with gastroschisis were more likely to have used aspirin during pregnancy and to have been taking oral contraceptives at the time of conception. Additionally, an increased incidence of illegal drug use (particularly cocaine) was noted among the study mothers. We conclude that gastroschisis is becoming the more common congenital abdominal wall defect, and that it could be related to exposure to an environmental teratogen.
ISSN:1015-3837
DOI:10.1159/000263620
出版商:S. Karger AG
年代:1991
数据来源: Karger
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5. |
Intrauterine Treatment of Thyroid Goiters |
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Fetal Diagnosis and Therapy,
Volume 6,
Issue 1-2,
1991,
Page 28-33
P. Sagot,
A. David,
M. Yvinec,
P. Pousset,
V. Papon,
A. Mouzard,
G. Boog,
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PDF (1699KB)
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摘要:
A fetal thyroid goiter detected by ultrasonography at 20 weeks of amenorrhea (WA) was diagnosed at 23 WA by a second ultrasound examination and a TSH assay in amniotic fluid. Since a sample of fetal blood at 27 WA showed that hypothyroidism was compensated and that goiter size and amniotic fluid volume were stable, intra-amniotic injection of 300 μg of L-thyroxine was delayed until 36 WA. This injection was performed before delivery to avoid potential perinatal complications (dystocia and neonatal respiratory distress) caused by large goiters
ISSN:1015-3837
DOI:10.1159/000263621
出版商:S. Karger AG
年代:1991
数据来源: Karger
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6. |
Twin-Twin Transfusion Syndrome during the 2nd Trimester Is Associated with Small Intertwin Hemoglobin Differences |
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Fetal Diagnosis and Therapy,
Volume 6,
Issue 1-2,
1991,
Page 34-36
N.J. Saunders,
R.J.M. Snijders,
K.H. Nicolaides,
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摘要:
In four twin pregnancies presenting with acute 2nd-trimester polyhydramnios due to presumed twin-twin transfusion syndrome, the fetal hemoglobin concentration was measured in samples obtained by cordocentesis. In no instance did the twin pair difference in the hemoglobin concentration exceed 2.7 g/dl.
ISSN:1015-3837
DOI:10.1159/000263622
出版商:S. Karger AG
年代:1991
数据来源: Karger
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7. |
Routine Examination by Ultrasound for the Detection of Fetal Malformations in a Low Risk Population |
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Fetal Diagnosis and Therapy,
Volume 6,
Issue 1-2,
1991,
Page 37-45
Vibeke Brocks,
Jens Bang,
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摘要:
A low risk population was offered screening for malformations in the second and third trimesters of pregnancy. Of 16,763 scans of pregnancies in the second trimester, 61 malformations were identified (0.36%). In the third trimester, scanning of 10,752 pregnancies revealed 24 malformations (0.22%): in all, in a low risk population 0.58% major malformations were found. The sensitivity for noncardiac malformations of the second trimester scanning was 54.3 with a specificity of 99.9%. The malformations overlooked was a more benign spectrum than the cases diagnosed. The sensitivity for cardiac malformations was less than 20%.
ISSN:1015-3837
DOI:10.1159/000263623
出版商:S. Karger AG
年代:1991
数据来源: Karger
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8. |
Fetal Nuchal Cystic Hygromata: Associated Malformations and Chromosomal Defects |
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Fetal Diagnosis and Therapy,
Volume 6,
Issue 1-2,
1991,
Page 46-57
G.B. Azar,
R.J.M. Snijders,
C. Gosden,
K.H. Nicolaides,
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摘要:
During a 6-year period (1985–1990), blood karyotyping was performed in 44 fetuses with septated, bilateral, dorsal, cervical cystic hygromata. This condition constitutes a different entity from nuchal oedema. There were 33 (75%) chromosomal abnormalities, including Turner’s syndrome (n = 31), trisomy 18 (n = 1) and trisomy 21 (n = 1). Congenital heart defects (CHD), mainly coarctation of the aorta, were present in 15 of the fetuses with Turner’s and in 1 of the chromosomally normal fetuses. The incidence of CHD was higher in the fetuses with ultrasonographic evidence of moderate/severe hydrops (41%; 13 of 32 cases) than in those with mild or no hydrops (25%; 3 of 12 cases). Although both the biparietal diameter (BPD) and femur length (FL) were reduced in all fetuses, the FL to BPD ratio was below the 5th percentile in 29 of the 33 (88 %) chromosomally abnormal fetuses, but in only 4 of the 11 (36%) chromosomally normal ones. In the chromosomally normal group, 3 of the fetuses had multiple pterygium syndromes, and in such cases the risk of recurrence may be high. In contrast, in the group of mutant chromosomal disorders with monosomy or trisomy, the risk of recurrence is in the order
ISSN:1015-3837
DOI:10.1159/000263624
出版商:S. Karger AG
年代:1991
数据来源: Karger
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9. |
Doppler Study of Uterine Artery Blood Flow: Comparison of Findings in the First and Second Trimesters of Pregnancy |
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Fetal Diagnosis and Therapy,
Volume 6,
Issue 1-2,
1991,
Page 58-64
P. Kaminopetros,
M.T. Higueras,
K.H. Nicolaides,
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摘要:
In 55 women with singleton pregnancies, colour flow mapping and pulsed wave velocimetry were used to measure impedance to flow in the uterine arteries at 10–13 weeks gestation and again at 19–22 weeks. In the first trimester, examinations were performed both transabdominally and transvaginally and in the second trimester transabdominally only. There were significant associations between the first- and second-trimester measurements obtained with both Doppler techniques. These associations were higher when transvaginal than transabdominal Doppler was used and when the measurement of impedance was the pulsatility index (PI) rather than the resistance index. These data suggest that impedance to flow in the uteroplacental circulation in the second trimester is dependent on impedance in the first trimester. In any prospective, first-trimester, uterine artery Doppler screening study for pregnancy complications, it may be preferable to use transvaginal Doppler and measure
ISSN:1015-3837
DOI:10.1159/000263625
出版商:S. Karger AG
年代:1991
数据来源: Karger
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10. |
Using Ultrasonic Measurement of Cardiac Size in Predicting Congenital Heart Defect |
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Fetal Diagnosis and Therapy,
Volume 6,
Issue 1-2,
1991,
Page 65-73
Jeng-Hsiu Hung,
Heung-Tat Ng,
Kai-Shin Shei,
Ya-Ping Pan,
Kuo-Tong Yen,
Ming-Jie Yang,
Man-Li Yang,
Li-Ping Shu,
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摘要:
A Duplex Color apparatus equipped with real-time imaging and Doppler sector scanner was used to scan fetal hearts, ranging from 17 to 41 weeks gestational age. A total of 323 normal fetuses were studied. The four-chamber view was obtained in a horizontal section just above the level of the fetal diaphragm. Five variables of the Chinese fetal heart in relation to the width of the right ventricle, width of the left ventricle, ratio of right ventricle/left ventricle (RV/LV), length of the fetal heart and the cardiac volume of a four-chamber view were set against gestational age in weeks and expressed in regression equations. The ratio of RV/LV is quite constant in relation to the gestational age. The mean ranges between 0.9916 for 17 weeks gestation and 1.0045 for a term fetus. In 10 abnormal cases with congenital cardiac defects, using the 5th and the 95th percentiles of this normal data as cutoff points, the RV/LV ratio had the highest sensitivity rate of 70% (7/10) in predicting fetal cardiac anomaly. The width of the left ventricle was the second most sensitive parameter with a sensitivity of 4/10 (40%). The RV/LV ratio of a four-chamber view is a simple, time-saving screening parameter for predicting congenital cardiac defects antenatally.
ISSN:1015-3837
DOI:10.1159/000263626
出版商:S. Karger AG
年代:1991
数据来源: Karger
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