ISSN:0955-8829    

出版商:OVID    

年代:1992

数据来源: OVID

摘要:

Expanded analyses of the NIMH Collaborative Study family data on bipolar disorder showed that an earlier suggestion of non-Mendelian transmission was dependent on the definition of the liability indicator. When an appropriate liability indicator was used. polygenic and generalised single major locus models were almost equally compatible with the data.

ISSN:0955-8829    

出版商:OVID    

年代:1992

数据来源: OVID

摘要:

Huntington's disease (HD) is reported in one indigenous Fijian family and one Indian Fijian family. The age of onset appears to be earlier than that found in Caucasian populations. The existence of more than one HD allele is a likely explanation.

ISSN:0955-8829    

出版商:OVID    

年代:1992

数据来源: OVID

摘要:

Twenty-one multiplex bipolar (BP) families, consisting of 365 informative persons (of whom 153 have BPI, schizoaffective, BPII with major depression or recurrent unipolar diagnoses) were studied in a systematic screening of chromosomes 1, 10q, 11q, 13, 15 and 17 for linkage, using DNA markers. Simulation research has indicated that this pedigree series has greater than 50% power to detect linkage when only 25% of families are linked (1% recombination) to the marker. Two and three-point linkage analysis (using the diagnoses mentioned above as affected and an autosomal dominant disease mode1) did not reveal any evidence for linkage (total lod scores less than - 2) under the hypothesis of homogeneity. Inspection of two-point lod scores by family did not reveal evidence for heterogeneity in nearly all cases. Heterogeneity analyses using the admixture test were conducted for a region of 11q13 (where inspection of 2-point analyses for individual families revealed several weakly positive lod scores) which yielded a maximum lod score of 1.5 when the fraction of linked families was estimated at 25%. These results indicate that a gene responsible for BP disease in a majority of the families studied is unlikely to originate within the chromosomal regions covered by the DNA markers used.

ISSN:0955-8829    

出版商:OVID    

年代:1992

数据来源: OVID

摘要:

Smooth pursuit eye movement (SPEM) was examined in members of two Palauan families, one with eight cases and the other with six cases of schizophrenia. Abnormal eye-tracking was present in 63% of the schizophrenic patients studied and in 53% of the first-degree relatives studied. These proportions correspond closely to those found in studies of Caucasian families with multiple incidence of schizophrenia.

ISSN:0955-8829    

出版商:OVID    

年代:1992

数据来源: OVID