ISSN:0955-8829    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

In sum, the Park City Conference provided a conducive environment for data presentation and interaction among investigators. Over the past year much progress has been made, including advances in the ascertainment of families, genotyping and analytic methods. A critical mass in the field appears realized and major advances may be forthcoming.

ISSN:0955-8829    

出版商:OVID    

年代:1995

数据来源: OVID

ISSN:0955-8829    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

Alterations in γ-aminobutyric acid (GABA) neurotransmission have been indirectly implicated in the pathogenesis of schizophrenia. Using nine multiplex pedigrees, we tested for linkage between schizophrenia and simple sequence repeat polymorphisms for the GABAAreceptor α1, α2, α4, α5, α6, β1 and β3 subunit genes. Evidence of linkage was not found when assuming either autosomal dominant or autosomal recessive inheritance. The non-parametric sib pair test also did not reveal significant evidence of deviation from expected segregation ratios.

ISSN:0955-8829    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

Nine multiplex schizophrenia families were genotyped with 15 microsatellite markers mapping to the short and long arm of chromosome 18. Assuming either autosomal dominant or recessive inheritance evidence of linkage was not found. In addition, the non-parametric sib pair test did not reveal significant evidence of linkage.

ISSN:0955-8829    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

The authors report findings from a blind, controlled study of obsessive-compulsive disorder (OCD). Prevalence rates of generalized anxiety disorder (GAD) and major depressive disorder (MDD) were compared among first-degree relatives of probands with OCD and co-morbid GAD or MDD, respectively. Rates of MDD were not increased in relatives of probands with OCD and MDD; neither were rates of GAD increased in relatives of probands with OCD and GAD, although rates of GAD were increased among relatives of probands with OCD compared to relatives of healthy controls. The authors explore the implications of the findings.

ISSN:0955-8829    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

Attempts to detect anticipation in datasets have been hampered by two statistical problems: confusion about the role of correlation, and ascertainment bias. We show three things. (1) Correlation and anticipation are two distinct phenomena, such that neither high nor low correlation necessarily reveals anything about anticipation. (2) Nor does correlation analysis (or its cousin, regression analysis) offer a way to detect ascertainment bias, as has been suggested. Demonstration of “regression to the mean” does not necessarily indicate the presence of ascertainment bias, either. (3) Finally, under certain special circumstances, one can test for anticipation without regard for ascertainment bias. However, these circumstances are limited and may prove of little practical value.

ISSN:0955-8829    

出版商:OVID    

年代:1995

数据来源: OVID