ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1978.tb05791.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1978.tb05792.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1978.tb05793.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1978.tb05794.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

During a follow‐up period of six to 12 years, 15.4% of patients in the Queensland Melanoma Project (Q.M.P.) developed histologically proven secondary deposits in lymph nodes. The incidence rate in males (21%) was twice that in females (11%), but the mortality rate was similar (M., 67%; F. 61%). Thirty‐two patients (2%) had positive nodes with no known primary lesion. Metastases developed in males with lesions on the foot (50%), on the thigh (29%), and on the back (22%); and in females with lesions on the lower leg (9%) and thigh (20%). About one‐half of the nodes were removed at the time of treatment of the primary growth or within two months. Three‐quarters were removed in the first year. However, it was found that tumour could remain dormant for more than eight years. Dormant tumours behaved in a similar aggressive fashion on regrowth as non‐dormant secondaries. Nodal metastases were present in 5% of patients at the time of their first presentation with primary melanoma. Elective node dissections were done in 6% of males and 11% o

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1978.tb05795.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The neurological manifestations of melanoma are analysed in this review of 1,500 patients in the Queensland Melanoma Project from 1963 to 1969. Three hundred and fifty patients have died, and 113 were recognized as having central nervous system metastases. The natural history of these metastases was examined, together with the results of a limited number of autopsies. The results of treatment are discussed.

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1978.tb05796.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Determination of urine cysteinyldopa excretion is the most sensitive chemical test for the detection of melanoma metastases and has been successfully applied during the Scandinavian winter, when sun irradiation is low. The value of this determination, under Australian conditions of greater sun irradiation, has been assessed by comparing the cysteinyldopa excretion of patients with that of normal subjects exposed to sunlight. Cysteinyldopa is an intermediate in the biosynthesis of the red‐brown pnaeomelanin.Of 20 patients without known secondary melanoma, the cysteinyldopa concentration of “spot” urines ranged from 0 to 190 (mean 48) μg/ml; of six known to have local metastases, 0 to 80 (mean 19) μg/ml; and of four known to have extensive metastases 80 to 1350 (mean 330) μg/ml.The effect of sun irradiation alone was assessed in nine healthy subjects followed one to 11 weeks before and after recorded periods of sun exposure. The cysteinyldopa concentrations of 24‐hour urines ranged from 40 to 3100 μg/ml. Increases occurred three to 10 days following sun exposure and were greatest following multiple small exposures in an individual with “Celtic” complexion.It is concluded that measurement of cysteinyldopa concentration would be of value in the follow‐up of melanoma patients in Australia only if patients could be persuaded to live under conditions free of all direc

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1978.tb05797.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The clinical and histological features of the Spitz naevus are reviewed in the light of a recently reported study of 211 cases seen at the Queensland Melanoma Project.

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1978.tb05798.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The growth rate of pulmonary metastases was determined in 18 patients with pulmonary metastases from histologically proven malignant melanoma. From chest radiograms 81 metastases were measured 51 consecutive times, and 120 values for doubling time were obtained. Metastases with diameters of 15.0 mm or less grew significantly faster (arithmetic mean 24 9 days) than metastases with diameters over 15.0 mm (arithmetic mean=51. Odays). The difference is statistically significant (P<0.050). In about one‐tenth (9.2%) of all measurements the values for doubling time are considerably lengthened (arithmetic mean=182.2 days). The determination of doubling time values may be considered as a useful parameter in the selection of patients for treatment of pulmonary metastases from malignant melanom

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1978.tb05799.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Previous studies have shown that many melanoma patients have cytotoxic leucocyte‐dependent antibody (LDA) which is inhibited by factors in their sera. These factors were shown to be small molecular weight glycoproteins which could also be identified in the supernatants of melanoma cultures, and which were therefore most likely to be melanoma cell surface antigens. The present studies have shown that these blocking factors against melanoma LDA can be detected in patients with primary melanoma, and that the levels of this activity show an inverse correlation with the levels of LDA in the sera of melanoma patients. The appearance of melanoma LDA after surgery for localized melanoma was shown in approximately a third of the patients, and this pattern was shown to result from the disappearance of the LDA blocking activity after surgical removal of the melanoma. Assays were designed specifically to measure the melanoma LDA blocking factors by plasmapheresis. It is not yet known whether the melanoma LDA blocking activity has correlation with tumour growth in melanoma patients. The potential value of measuring this activity to assess response to therapy was shown by studies designed to remove the blocking factors by plasmapheresis. It is not yet known whether the melanoma LDA blocking activity has biological significance in regard to tumour growth, but these studies appear to indicate that measurement of these factors in the sera of melanoma patients may provide a usefulin vitromonitor of tumour growth in melanoma patient

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1978.tb05800.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY