ISSN:0251-5350    

DOI:10.1159/000110842

出版商:S. Karger AG    

年代:1984

数据来源: Karger

ISSN:0251-5350    

DOI:10.1159/000110843

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

The epidemiology of multiple sclerosis (MS) in Finland has been under continuous investigation since 1964. A small rural area in the western part of the country was selected for detailed familial analysis. In this area the prevalence ratio was 101/ 100,000 and the age-adjusted mean annual incidence 4.1/100,000. Of 51 probands, 29% had a second case of MS in their family. In the 51 sibships, 236 sibs were alive and 8% of them were familial cases of MS. The recurrence risk of MS for sibs was 2.5%. This means that MS occurs 25 times more often among sibs of MS patients than in the general population of the same geographic area. Of living sibs, 60% were still at risk for subsequent MS.

ISSN:0251-5350    

DOI:10.1159/000110844

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

If patients with parkinsonism were the only users of antiparkinsonian drugs and the drugs were utilized by the majority of the patients, the prevalence of the disease could be estimated from information on drug sales. The present study examines whether these prerequisites are fulfilled and whether the quality of the information on antiparkinsonian drug utilization in Sweden is sufficient for epidemiological use. Information on the use of antiparkinsonian drugs was collected from different registers of the Swedish National Corporation of Pharmacies. The quality of the data was good and made it possible to calculate the age-specific use of drugs by patients with parkinsonism. Levodopa derivatives (L-dopa + decarboxylase inhibitors) were found to be the best tracers for parkinsonism.

ISSN:0251-5350    

DOI:10.1159/000110845

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

A mathematical model has been constructed to estimate the prevalence of parkinsonism from register information on the use of a tracer drug in a defined geographical area. The prevalence of parkinsonism was estimated for several European countries using data on rates of L-dopa derivatives in 1980. The estimates were compared with data from community-based surveys of parkinsonism. The precision of the estimates as calculated by the coefficient of variation ranged between 1.6 and 6.9% and the accuracy as measured by the standard deviation of the percent error was 9.1 %. Up-to-date community-based data are not available. Using this calibrated model, the prevalence of parkinsonism in Sweden was estimated as 167.9/100,000.

ISSN:0251-5350    

DOI:10.1159/000110846

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

The published data of 34 studies of the long-term prognosis after transient ischaemic attacks (TIA) have been analysed. Despite the different types of investigation, the results, once the initial period of follow-up has been discounted, are consistent. The results indicate that, from approximately 1 year after onset of TIAs, the hazard rate is approximately constant and the level of excess annual mortality relative to general population experience is approximately 85%. At present, the data available to distinguish which is the superior between these two alternative descriptions of the long-term experience following TIA are not available.

ISSN:0251-5350    

DOI:10.1159/000110847

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

The published data of 34 studies of the long-term prognosis after transient ischaemic attacks (TIA) have been analysed. Despite the different types of investigation, the results, once the initial period of follow-up has been discounted, are consistent. The results indicate that, from approximately 1 year after onset of TIAs, the hazard rate is approximately constant and the level of excess annual mortality relative to general population experience is approximately 85%. At present, the data available to distinguish which is the superior between these two alternative descriptions of the long-term experience following TIA are not available.

ISSN:0251-5350    

DOI:10.1159/000110848

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

In 515 cases of motor neuron disease followed until death, (1) the proportion of three subtypes of motor neuron disease (MND): amyotrophic lateral sclerosis (ALS), progressive bulbar paralysis (PBP), spinal progressive muscular atrophies (SPMA) was 78.3, 1.9, 19.8; (2) sex ratios were 1.41 in ALS, nearly one in PBP and 1.59 in SPMA, the ratio being high in cases initially involving the upper limbs; (3) age at onset was smoothly unimodal and identical in three subtypes; (4) bulbar symptoms appeared either at the initial stage or towards the fatal end; (5) duration was compatible with a compound Weibull distribution; (6) survival rates showed a reverted J type distribution and was more favorable in SPMA than ALS; (7) life expectancies decreased first but increased about 46 months after onset; (8) multivariate analysis disclosed that duration is shorter in ALS when age at onset was older, and when bulbar muscles or left limbs were initially affected, and in SPMA when age at onset was older, dysphagia was present, and probably in those patients who had a history of trauma.

ISSN:0251-5350    

DOI:10.1159/000110849

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

In 515 cases of motor neuron disease followed until death, (1) the proportion of three subtypes of motor neuron disease (MND): amyotrophic lateral sclerosis (ALS), progressive bulbar paralysis (PBP), spinal progressive muscular atrophies (SPMA) was 78.3, 1.9, 19.8; (2) sex ratios were 1.41 in ALS, nearly one in PBP and 1.59 in SPMA, the ratio being high in cases initially involving the upper limbs; (3) age at onset was smoothly unimodal and identical in three subtypes; (4) bulbar symptoms appeared either at the initial stage or towards the fatal end; (5) duration was compatible with a compound Weibull distribution; (6) survival rates showed a reverted J type distribution and was more favorable in SPMA than ALS; (7) life expectancies decreased first but increased about 46 months after onset; (8) multivariate analysis disclosed that duration is shorter in ALS when age at onset was older, and when bulbar muscles or left limbs were initially affected, and in SPMA when age at onset was older, dysphagia was present, and probably in those patients who had a history of trauma.

ISSN:0251-5350    

DOI:10.1159/000110850

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Mortality data for the entire US for 20 categories of neurologic disease for the years 1971 and 1973–1978 were reviewed. Data were analyzed separately for deaths due to each disease (i.e., with the disease listed as the underlying cause of death) and for deaths related to the disease (i.e., with the disease listed as the underlying, immediate, associated, or contributory cause of death). Average annual age-, race-, and sex-specific mortality rates for deaths due to and deaths related to each of 20 neurologic disorders were calculated using as the denominator population estimates by age, race, and sex for the same years, obtained from a linear interpolation of the 1970 and 1980 US census data. Average annual age-adjusted mortality rates by race and sex were also calculated. The percent distribution of the registered underlying cause of death in people dying with each of the 20 categories of neurologic disease was also determined. Examination of these data emphasizes the importance of checking all deaths related to a disease to obtain more complete information about the disease from mortality dat

ISSN:0251-5350    

DOI:10.1159/000110851

出版商:S. Karger AG    

年代:1984

数据来源: Karger