摘要:

This report concerns 347 patients with primary hydatidiform moles studied during the first 6 years (1966–1972) of operation of the Southeastern Regional Trophoblastic Disease Center. Aside from a decreased incidence, molar pregnancy in the United States follows a pattern similar to that elsewhere in the world. Abnormal bleeding is the key to early diagnosis, and the frequent use of sensitive HCG assays is the key to proper followup. Twenty percent of patients with hydatidiform moles can be expected to develop subsequent malignant sequelae. Bilateral ovarian enlargement and/or a large-for-dates uterus should alert the physician to a greter poential for this outcome. Spontaneous elimination of HCG from the circulation following molar pregnancy, as indicated by sensitive assay, would predict a benign postmolar course; no patient in the current series who once achieed undetectable levels of HCG developed malignant trophoblastic disease.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

The incidence of galactorrhea in 480 ovulatory females was compared to that in 383 anovulatory females. One percent of the ovulatory and 3.2% of the anovulatory patients had bilateral galactorrhea. The probability (P) of these two groups being from the same population was less than 0.02.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Fifteen years's experience with the adrenogenital syndrome at Duke University Medical Center is reviewed. Twenty-six patients were diagnosed before age 2. Of these, 20 had the salt-losing syndrome. The complications encountered and the results obtained in terms of growth, development, and fertility are discussed. Delay in diagnosis nad inappropriate gender assignment continue to be a problem.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Five new patients with postmenarchial onset of adrenal virilism related to 21-hydroxylase deficiency are presetned. Diagnostic criteria are reviewed. Four pregnancies resulting in 3 term infants occurred after instigation of therapy. Eleven patients similar in clinical presentation are reviewed for comparison. Findings of value in distinguishing these two groups of patients are discussed.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Daily blood samples were obtainedfrom 5 postmenopausal patients for 21 days and analyzed for plasma follicle stimulating hormone (FSH), luteinizing hormone (LH), esteonr, estradiol, progesterone, and serum T4. On days 8 through 14, oral thyrotropin-releasing hormone (TRH) was administeted, 50 mg, 4 times a day. All patients showed a significant T4, response. There was, however, no significant change in the plasma FSH, LH, estrone, estradiol, or progesterone. We conclude that oral administration of TRH has no influence on the elevated circulating concentration of FSH and LH seen in the postmenopausal female.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Eighty-nine pregnancies, at risk for placental insufficiency, were monitored with serial oxytocin challenge tests (OCT) and estriol determinations on 24-hour urine collections. Intraamniotic catheters were used to accurately record intrauterine pressure in 63% of the tests; 114 of the 116 tests (98%) were adequate for interpretation. Thirteen positive tests were recorded; however, in only 2 cases did the positive OCT predict a dysmature-postmature infant when estriol determinations were normal. Prompt delivery following a positive OCT can significantly reduce the incidence of fetal wastage.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Amniotic fluid α2-antitrypsin values were determined by radial immunodiffusion of 317 samples obtained between the 10th and 43rd weeks of gestation in normal pregnant patients and those with complications. Serial determinations of α2-antitrypsin values revealed that in normal patients values decreased as pregnancy advanced while vlaues increased as pregnancy advanced in cases in which there was severe Rh-allommunization and hydramnios. A wide range of values was observed for each week of gestation. Although there was a definite tendency for values to decrease as pregnancy advanced (60.8 mg/100 ml before 30 weeks and 17.9/100 ml after 40 weeks), the method must be regarded as unreliable for determining fetal maturity in cliincal practice. In the case of newborn infants with hyaline membrane disease, no decrease in amniotic fluid α2-antitrypsin values had been found.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Two additional cases of Guillain-Barré syndrome complicating pregnancy are reported and the 25 previously published cases reviewed. While fetal prognosis is generally favorable, the occurrence of the disease in late pregnancy is a high-risk maternal condition. Respiratory failure and aspiration pneumonitis may result in premature labor and maternal mortality.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Medical induction of labor was attempted in 30 women after intrauterine death of the fetus. Labor was induced in 15 patients with oxytocin and in an additional 15 patients with prostaglandin E2. The results suggest that prostaglandin has some advantage over oxytocin in these circumstances, and that prostaglandins may be especially useful in this difficult clinical situation.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A group of 60 patients between the ages of 30 and 45 were randomly selected to have either a suction curettage or dilatation and curettage. The criteria used for patient selection was that they had dysfunctional uterine bleeding, a normal gynecologic examination, and were receiving no hormonal therapy. These patients were followed up for at least 3 months. Althouth the number of patients is relatively small, the results showed that, therapeutically, suction currettage was equal to dilatation and curettage in alleviating dysfunctional uterine bleeding.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID