摘要:

Twenty-two women with galactorrhea and/or amenorrhea were evaluated. Thyroxine (T4), thyroid-stimulating hormone (TSH), and visual fields were normal. Hyperprolactinemia (22 to 440 ng/ml) was present in 19 patients. Evidence of tumor was found in 73.7% of the women, whereas 26.3% were classified as functional. Three patients with empty sella syndrome showed normal prolactin levels (12.2 to 18.5 ng/ml). There was a significant negative correlation between prolactin levels and follicle-stimulating hormone (FSH) (P<0.05), but not between prolactin and luteinizing hormone (LH) levels. Hypocycloidal polytomography was better than plain x-ray films in detecting early prolactin-secreting pituitary tumors (14 patients). Pituitary testing using an insulin tolerance test showed a statistically significant difference in human growth hormone (hGH) reserve between tumor and functional groups

ISSN:0029-7844    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

A study was undertaken to determine the incidence of increased serum levels of human prolactin (hPRL) in women during oral contraceptive therapy, and to correlate this with both the dose of oral contraceptive medication and the duration of its use. The 123 patients in this study were divided into 3 groups according to the dosage of estrogenic component of the combined oral contraceptives. Thirty percent of these women had hyperprolactinemia of varying degree. Neither the dosage of steroids within our range nor the duration of therapy correlated with the presence or degree of hyperprolactinemia. The actions of estrogen-progestin compounds on hPRL are discussed.

ISSN:0029-7844    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

Eighteen cases of acute and subacute puerperal inversion were studied to identify important predisposing factors and to assess management and postpartum morbidity. The study patients did not differ from case-matched controls in age, parity, duration of labor, type of delivery, or management of the third stage. The most common signs noted were hemorrhage (94%) and shock (39%). All inversions were recognized immediately and manually replaced within 60 minutes. Shock was treated prior to repositioning in all cases. Calculated blood loss averaged 1775 ml. There was no mortality nor febrile morbidity. The average hospital stay of the study patients and their case-matched controls was 3 days. Immediate recognition of uterine inversion and prompt initiation of therapy will ensure a normal postpartum course.

ISSN:0029-7844    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

An 8-year retrospective study was conducted of the metropolitan Dayton, Ohio, area from January 1970 through December 1977. During this period of time there were 86,809 births and 721 tubal pregnancies. Thirty-three of the ectopic pregnancies were in patients who had previously undergone a tubal sterilization. The 7.4% rate (29 of 393) in the past 4 years indicates the increasing importance of previous sterilization as an etiologic agent in ectopic gestation.

ISSN:0029-7844    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

To explain the sensitivity of uterine leiomyomata to endogenous and exogenous estrogens, specific cytosol receptor proteins for estradiol-17β and progesterone were found in tissue from uterine leiomyomata and compared with the concentrations of receptors in normal myometrium and endometrium from the same patient. The concentration of cytoplasmic estrogen receptors in leiomyomata (40.5 ± 7.6 fmole/mg cytosol proteins, mean ± SEM) was significantly greater than that found in myometrium (16.5 ± 1.5) and significantly less than that found in endometrium (131 ± 15.1). The concentration in leiomyomata of cytoplasmic progesterone receptors (104.4 ± 41.2 fmole/mg cytosol protein, mean ± SEM) was also greater than that found in myometrium (80.0 ± 29.9) and less than that of endometrium (194.7 ± 5.5); however, individual variation precluded statistical significance. The presence of cytoplasmic receptor proteins in myomatous tissues explains the sensitivity of the leiomyoma to endogenous or exogenous steroids and may provide information useful in the clinical management of this neoplastic disorder.

ISSN:0029-7844    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

The reproductive history of 69 women with demonstrated diethylstilbestrol (DES)-related cervical-vaginal abnormalities is reviewed. AH of the patients were sexually active non-contraceptive users who were studied over an 8-year period. Forty-six patients conceived, for an uncorrected fertility rate of 66.7%. Fourteen patients elected therapeutic abortion. The 32 remaining patients had 62 pregnancies which resulted in 26 living children, for a success rate of 41.9%. However, cervical cerclage was required for continuation of 8 of these successful pregnancies. The 36 pregnancy failures consisted of 19 first- and 11 second-trimester spontaneous abortions, 3 third-trimester losses due to prematurity, and 3 tubal pregnancies. Uterine abnormalities were found in all of the 25 patients who underwent liysterosalpingograins. Although other reproductive diseases unrelated to DES exposure in utero were also present in this select group of patients, it is probable that the high rate of infertility and pregnancy wastage is related to the uterine structural abnormalities encountered.

ISSN:0029-7844    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

The pharmacokinetics of doxycycline and cephalothin in genital tissues and serum were evaluated in 38 patients undergoing hysterectomy. Antibiotic concentrations in the ovary, fallopian tube, myometrium, cervix, and endometrium were measured at varying intervals after antibiotic administration. Cephalothin concentrations in tissues were critically dependent on the time interval between preoperative antibiotic administration and removal of the genital tract tissues, whereas doxycycline concentrations in tissues were consistently reproducible in the time frame evaluated (I to 4| hours after drug administration). Doxycycline endometrial concentrations were consistently higher than those measured elsewhere in the genital tract (P<0.05). These results are of importance in a reassessment of traditional approaches to antibiotic use in gynecologic surgery and in the management of pelvic inflammatory disease (PID).

ISSN:0029-7844    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

The effectiveness of oral contraceptives with concomitant use of ampicillin has been questioned. Eleven volunteer subjects were studied during 2 consecutive menstrual cycles; they were given Demulen with placebo or ampicillin during each of the cycles. Serum estradiol (E2), progesterone (P4), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were evaluated on days 13 and 19 of each cycle. Testosterone-binding globulin (TeBG) capacity and ferning of cervical mucus were evaluated on day 13 of each cycle. Subjective symptoms were recorded. All cycles appeared to be anovulatory. Steroid suppression was present in 10 of 11 patients during both cycles. Estrogendependent TeBG was not affected by ampicillin. It is possible that cervical mucus ferning was improved by concurrent ampicillin administration. Ampicillin appears unlikely to diminish the effectiveness of the oral contraceptive studied.

ISSN:0029-7844    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

Placenta! sonolucency has been reported to be a normal sonographic finding after 36 weeks' gestation. To further characterize this acoustic phenomenon, 15 placentas from previously scanned high-risk obstetric patients were studied in vitro. Placentas were obtained at delivery, and were washed, weighed, sonographically imaged in a water bath, x-rayed by xerography, and pathologically examined. Placental sonolucency occurred as early as 31 weeks' gestation and corresponded anatomically to cotyledons. The degree of septal calcification appeared to correlate best with the degree of sonolucency, and no unusual gross or microscopic placental features could be identified. Intrauterine growth retardation or intrauterine fetal death occurred in 8 of the 10 patients in whom there were sonolucent changes.

ISSN:0029-7844    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

The value of ultrasonic and hormonal methods [plasma human chorionic gonadotropin (hCG), estradiol (E2), and progesterone (P)] was examined in 188 patients exhibiting different forms of early pregnancy failure. A negative ultrasonic result in the detection of fetal life signs after 9 weeks' gestation signified an unsuccessful outcome for the pregnancy in 100% of cases. On the other hand, the ultrasonic demonstration of fetal life predicted delivery in 90% of cases despite symptoms of threatened abortion. Pathologic levels of hCG or P signified a later miscarriage in 93% of cases, and their combination correlated with a 100% failure rate. In the diagnosis of ectopic pregnancy the combined application of ultrasound and plasma hCG levels seemed to be very useful; however it appears that the detection of blighted ovum should be based on the ultrasonic scanning only. The results of the present study indicate that ultrasonic examination can be regarded as the basic diagnostic method in the evaluation of early pregnancy failure. The determination of plasma trophoblastic hormones (especially hCG) seems to add valuable information to the ultrasonic findings in the actual diagnosis and evaluation of the later course of pregnancy only until 9 weeks' gestation.

ISSN:0029-7844    

出版商:OVID    

年代:1980

数据来源: OVID