ISSN:1062-4821    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Major strides in the molecular biology of essential hypertension are currently underway.This haas tended to obscure the fact that a number of inherit ed disorder associate with low blood pressure exit and that these diseases may have milder and underrecognized phenotypes that contribute importantly to blood pressure variation in the general population.This review highlight some of the gene products that, if abnormal, could cause hypotension in some individuals.Diseases due to abnormalities in the catecholamine enzymes are discussed in detail. It is likely that genetic abnormalities with hypotensive phenotypes will be as interesting and diverse as those that give rise to hypertensive disorder

ISSN:1062-4821    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

The angiotensin I-converting enzyme gene is one of the major genes of the renin-angiotensin and Kallikrein-kinin system and is a candidate gene for several cardiovascular diseases for which genetic predisposition has been established.Based on nalysis of the level of the enzyme in plasma, genetic polymorphism of its expression has been well characterized. Use of a DNA marker on the angiotensin l-converting enzyme gene has shown that the gene polymorphism is located within the angiotensin l-converting enzyme gene itself. This review summarizes the results of various studies of this polymorphism in cardiovascular diseases and the hypotheses that can be proposed to explain this effect.

ISSN:1062-4821    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Recent progress in molecular genetics has raised expectations that the application of powerful new techniques to established animal models of hereditary hypertension may provide important new in sight into the genetic basis of human hypertension.Whereas these method provide exciting opportunities, we shall have to revise many traditional and established strategies used in hypertension research to recognize their full potential.Although it is probably naive to anticipate the quick identification of genes involved in the pathogenesis of human hypertension from this research, these method, if applied wisely,are likely to render important conceptual insight into the nature not only of hypertension and cardiovascular diseases but of polygenic disorder in general

ISSN:1062-4821    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:1062-4821    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Dopamine is one of the major natriuretic hormones, It acts as an autocrine or paracrine factor to inhibit Na+ transport in several tubular segments. Na+,K+-ATPase is an important target protein for dopamine. Studies of the tubular effects of dopamine have provided new information about the coupling of dopamine to intracellular signaling systems and about the molecular mechanism for dopamine interaction with other hormones. Several lines of evidence now suggest that abnormalities of the renal dopamine system can lead to salt-sensitive hypertension.

ISSN:1062-4821    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

The molecular cloning and characterization of receptors for [Arg8] vasopressin and oxytocin were recently accomplished. These receptors form a subfamily among the large number of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors with seven transmembrane domains. The molecular cloning of the human V2 receptor was rapidly followed by the identification of mutations in the V2 receptor gene segregating with the clinical phenotype in families with X-linked nephrogenic diabetes insipidus. These naturally occurring mutations will be useful to identify critical functional regions of the vasopressin V2 receptor. Carrier detection and early diagnosis of affected male infants are available and can avert the physical and mental retardation that are the consequences of episodes of dehydration. Together with the recent cloning of the vasopressin-regulated water channels in the apical membrane of the collecting tubule, these developments will enable direct investigation of the mammalian concentrating mechanism.

ISSN:1062-4821    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Transforming growth factor-P (TGF-p) is a cytokine that is important in embryogenesis, development, carcinogenesis, and tissue repair. TGF-P is unique among cytokines in its widespread actions on the regulation of extracellular matrix. In a model of acute mesangial proliferative glomerulonephritis, it was shown that overproduction of TGF-p is the cause of pathologic matrix accumulation in the nephritic glomeruli. TGF-P acted to increase matrix production, inhibit matrix degradation, and modulate matrix receptors in the glomerulonephritic rats. Elevated expression of TGF-p was also found in other experimental glomerular diseases, including diabetic nephropathy. Studies of humans with glomerulonephritis and diabetic nephropathy also strongly implicated TGF-P in the pathogenesis of glomerular matrix build-up. Recently, the proteoglycan decorin was shown to neutralize TGF-p. When injected into glomerulonephritic rats, decorin markedly suppressed pathologic matrix deposition in the glomeruli. Thus, decorin offers hope as a treatment for progressive kidney diseases caused by the overproduction of TGF-β

ISSN:1062-4821    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Recently, the 24-hydroxylase enzyme of 25-hydroxyvitamin D3 was purified from rat and chick kidney, and its complementary DNA was cloned. The length of the rat 24-hydroxylase gene is about 15 kbp with 12 exons. Cloning of the 24-hydroxylase gene made it possible to examine the mechanism of regulation of vitamin D metabolism at the gene level. Expression of renal 24-hydroxylase mRNA is regulated by a balance of plasma parathyroid hormone and 1a,25-dihydroxyvitamin D3 levels, whereas intestinal 24-hydroxylase mRNA is regulated mainly by plasma 1a,25-dihydroxyvitamin D3. This article reviews recent progress in understanding the molecular aspects of vitamin D metabolism

ISSN:1062-4821    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:1062-4821    

出版商:OVID    

年代:1994

数据来源: OVID