摘要:

This bibliography is compiled by obstetricians and gynecologists from the journals listed at the end of this publication. It is based on literature entered into our database between 1 July 1995 and 30 June 1996 (articles are generally added to the database about two and a half months after publication). In addition, the bibliography contains every paper annotated by reviewers; these references were obtained from a variety of bibliographic databases and published between the beginning of the review period and the time of going to press. The bibliography has been grouped into topics that relate to the reviews in this issue.

ISSN:1040-872X    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Ovarian cancer has been described in association with three autosomal dominant syndromes: familial site-specific ovarian cancer, familial breast and ovarian cancer, and the hereditary nonpolyposis colon cancer syndrome. It appears that most breast-ovarian and site-specific ovarian cancer families are explained by mutations in theBRCA1tumor suppressor gene. Other genes associated with inherited susceptibility to ovarian cancer includeBRCA2, p53,and the DNA mismatch repair genes.

ISSN:1040-872X    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Although the nature of the cancer antigen 125 leaves many questions unanswered, the use of serum measurements as a means to assess the response to surgery and chemotherapy in ovarian cancer is now well documented. Good prognostic significance is attributed to a rapid decline in cancer antigen 125 levels after chemotherapy in patients with advanced ovarian cancer. Pre-operative serum cancer antigen 125 levels may successfully discriminate benign from malignant adnexal masses in postmenopausal women, but in women in their reproductive years the specificity is low. In stage I ovarian cancer patients, high preoperative cancer antigen 125 levels are reported to lead to a sixfold increase in the risk of dying from the disease. Low expectations on the specificity and outcome of cancer antigen 125-based screening of asymptomatic women are contradicted by the first results of screening programmes for postmenopausal women. Large, randomized, controlled studies will assess if survival can be improved by early detection of ovarian cancer

ISSN:1040-872X    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Paclitaxel and docetaxel are active in the treatment of patients with advanced ovarian cancer. The taxanes in various dose schedules achieve response rates of 10–50% with a median overall survival of 10–12 months in patients with platinum-refractory disease. Paclitaxel has activity in chemotherapy-naive patients when administered alone or in combination with platinum. The role of intraperitoneal paclitaxel remains to be defined.

ISSN:1040-872X    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Adenocarcinoma of the cervix may well be aetiologically, epidemiologically, and clinically different to its squamous counterpart. Overall prognosis is poorer which may relate to an increased radiation resistance or to a propensity to spread intraperitoneally. The role of neoadjuvant and adjuvant therapy is even less well defined than in squamous cancers. Future studies in carcinoma of the cervix should either be confined to one histological type, or should at least be stratified, based on whether the disease is squamous or non-squamous

ISSN:1040-872X    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:1040-872X    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:1040-872X    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Recent progress in pelvic exenteration includes the use of continent intestinal reservoirs (e.g. Kock, Indiana and Mainz pouch) instead of the ileal conduit (Bricker), use of myocutaneous flaps to cover the vulvar or perineal defect, better knowledge of the long term side effects of intestinal reservoirs and conduits, and suggestions for new indications such as pelvic sidewall relapse of cervical carcinoma with palliative or even curative intent

ISSN:1040-872X    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:1040-872X    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Markers for cell proliferation and cell loss have been extensively assessed in gynaecological cancers as potential diagnostic tools and prognostic indicators. Although they have been found to be useful as research devices in the study of oncogenesis, their role in clinical application remains to be elucidated.

ISSN:1040-872X    

出版商:OVID    

年代:1997

数据来源: OVID