ISSN:8755-1039    

DOI:10.1002/dc.2840050102

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractLipoidpneumonia (LP) is an uncommon entity with the characteristic radiographic features and histologic findings of alveoli filled with vacuolated, lipid‐laden histiocytes. We questioned whether bronchoalveolar lavage (BAL) could be useful in the confirmation of LP. We examined lipid stains (oil‐red O) in BAL specimens from 18 cases, representing a variety of pulmonary disease states, and compared them with an index case of confirmed LP. The index case of LP had a history of chronic intranasal use of mentholated petrolatum with subsequent x‐ray findings of progressive air bronchograms. Positive histochemical confirmation (oil‐red O) performed on frozen sections of transbronchial lung biopsy was obtained. Eleven of the non‐LP cases had no intracellular staining of BAL macrophages with oil‐red O stain, whereas the index case of LP exhibited markedly positive intracytoplasmic staining of macrophages for lipid. The remaining seven cases showed minimal to mild lipid staining with only one other case having moderate staining. This study demonstrates that BAL macrophages from patients with a variety of pulmonary states and without suspected LP do not demonstrate significant staining for intracellular lipids, in contrast with the expected strong positivity of LP. Lipid staining of BAL specimens, although not entirely specific may be a preferred method for confirming the diagnosis of LP. thereby avoiding more invasive

ISSN:8755-1039    

DOI:10.1002/dc.2840050103

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractOur original technique of preparing urinary and seminal sediment was modified in order to identify neoplastic cells in cases of testicular malignancies. In a series of 24 patients with testicular tumor‐like conditions, 18 tumors were diagnosed, 12 cytologically. In one case, the result of cytological examination was falsely positive since histopathology revealed necrosis of the testicle only. The morphology of neoplastic cells in the seminal sediment is demonstrate

ISSN:8755-1039    

DOI:10.1002/dc.2840050104

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractFrom 1977 to 1986, 39 cases at our institution were diagnosed as “consistent with mesothelioma” by percutaneous fine‐needle aspiration biopsy. All were verified clinically andlor histologically, with no false‐positive results. All mesotheliomas except four tumors of peritoneal origin originated from the pleura. On the basis of their cytomorphologic features in correlation with histopathology, the tumors were classified into four types: benign, carcinomatous, sarcomatous, and undifferentiated. Of these 39 cases of mesothelioma diagnosed by aspiration biopsy, nine were benign type; 14, carcinomatous type; 13, sarcomatous type; and three, undifferentiated type. The cytomorphologic features and patterns of different types of mesotheliomas observed in aspirate preparations are presented, and the differential diagnosis is discussed. It appears feasible to investigate pleural‐ or peritoneal‐based lesions with fine‐needle aspiration biopsy, particularly in patients without effusions or with negative results in effusion examinations. It is also possible to make a definitive diagnosis of mesothelioma on the basis of cytologic findings coupled with special and immunoperoxidase staining in combination with roentgenographic findings and cli

ISSN:8755-1039    

DOI:10.1002/dc.2840050105

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractWe describe the cytomorphology of seven cases of metaplastic carcinoma of the breast studied by fine‐needle aspiration cytology and by histology. All seven cases contained foci of ductual adenocarcinoma. This finding was combined with heterologous mesenchymal elements in four cases, a spindlecell pattern of growth in one case, and extensive squamous‐cell metaplasia in two cases. Both carcinomatous and metaplastic components were present on smears in four cases (57%). Thus in three cases (43%), the diagnosis was not possible on smear material alone. Differential diagnostic considerations are discus

ISSN:8755-1039    

DOI:10.1002/dc.2840050106

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractTwenty‐three cases of cystosarcoma phyllodes of the breast were studied clinically and by fine‐needle aspiration (FNA) cytology as well as by tumor histology. The median patient age was 52 yr. The total actuarial survival at 5 yr was 90%, and the recurrence‐free survival was 70%. A combination of stromal elements (tissue fragments and/or single spindle cells) and epithelial tissue was required to make the diagnosis on smear material. In FNA smears, stromal elements were absent in two cases, and ductal elements were not seen in three. Thus, the dimorphic pattern essential to this diagnosis was not present in five (22%) cases. An evaluation of tumor factors reported to be of prognostic significance was performed on histologic sections of resected tumors. Comparison of these data with FNA results indicates that little prognostic information can be obtained from FNA alone in most

ISSN:8755-1039    

DOI:10.1002/dc.2840050107

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractThis study of 160 consecutive fine‐needle aspirates of localized hepatic masses analyzed the efficacy of the technique when extended into a multicenter setting. The aspirates were processed and interpreted by a single cytology service, but they were performed, under radiographic imaging, in eight different hospitals by at least 20 radiologists, few of whom had had the opportunity to acquire long‐term experience. of 108 malignancies, 101 were correctly sampled (sensitivity, 93.5%), including 30 primary hepatocellular carcinomas, 70 metastatic tumors, and I lymphoma. Specific benign pathologic lesions in 12 cases were amenable to cytodiagnosis. The problem of the remaining 47 samples, which contained exclusively blood, necrotic material, or normal and reactive hepatic constituents, was addressed at length. These were considered “nondiagnostic” samples in the context of aspirating focal masses. The majority had benign lesions on further study, but tumors were found in seven, all of which had been sampling errors, resulting in a negative predictive value of 82.5%. Fine‐needle sampling of localized lesions, particularly neoplasms, can thus perform well in transition from single‐center studies to more widespread usage in daily practice. Confident reliance on the procedure can be maintained if appropriate radiologic and cytologic facilities exist, provided that the limitations of nonneoplastic aspirates are fully

ISSN:8755-1039    

DOI:10.1002/dc.2840050108

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractRoutinely processed fine‐needle aspirations of metastatic squamous‐cell carcinoma (SCC) were analyzed for human papillomavirus type 16 (HPV‐16) using the polymerase chain reaction (PCR), an in vitro DNA amplification method. HPV‐16 DNA was detected in five of seven (71%) metastases from SCC of the uterine cervix. In two cases in which the primary tumor was available for comparison, the HPV‐16 DNA content of the primary tumor and of the metastasis was identical. HPV‐16 was not found in a metastatic SCC from the lung or in a metastatic nasopharyngeal SCC. These findings demonstrate that HPV‐16 DNA sequences can be readily detected in routinely processed fine‐needle aspirations using the polymerase chain reaction. The finding of HPV‐16 DNA in a metastasis may serve to direct a search for a prima

ISSN:8755-1039    

DOI:10.1002/dc.2840050109

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractOver the past 6 yr, we have observed an increase in cytologic specimens from the respiratory tract in patients suspected or known to have AIDS, from 7 of 81,031 cases in 1982 to 1,231 of 55,333 in 1987. Based on our experience with 1,140 patients, this article reviews the technical and morphologic evaluation of pulmonary cytologic specimens from AIDS patients.

ISSN:8755-1039    

DOI:10.1002/dc.2840050110

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractImmunohistochemical technique is now successfully applied to the cytologic materials. This review article describes details of staining procedures for immunocytochemistry at both light and electron microscopic levels. The clinical application of the technique includes aspiration biopsy cytology for breast lesions, thyroid lesions, lymph nodes, the nervous system, and others. The establishment of carcinoma cells in the body fluid by the demonstration of carcinoembyronic antigen (CEA) and the establishment of specific diagnoses in small‐cell or largecell anaplastic tumors by immunocytochemistry warrants special emphasi

ISSN:8755-1039    

DOI:10.1002/dc.2840050111

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY