ISSN:8756-0437    

DOI:10.1002/ssu.2980060102

出版商:John Wiley&Sons, Inc.    

年代:1990

数据来源: WILEY

摘要:

AbstractEarly‐stage esophageal carcinomas are extremely difficult to detect because the patients have no complaints, and findings on the X‐rays are nil. Lugol‐combined endoscopy is the most effective method for detecting the presence of small carcinoma of the esophagus. This paper was, first, conducted on the diagnostic features of early‐stage esophageal carcinoma, detected through the use of Lugol‐combined endoscopy. As the prognosis of patients with esophageal carcinoma is related to many factors, we investigated the prognostic contribution of 15 discrete variables with multivariate analysis. The variables are resectability of the malignant lesion, DNA distribution pattern of the cancer cells, and postoperative complications. As the DNA pattern of cancer cells cannot be changed by surgeons, early detection and postoperative care play key roles in determining the survival of patients with esophageal

ISSN:8756-0437    

DOI:10.1002/ssu.2980060103

出版商:John Wiley&Sons, Inc.    

年代:1990

数据来源: WILEY

摘要:

AbstractHyperthermia is effective for the treatment of carcinoma when applied concomitantly with chemotherapy and irradiation. However, it is difficult to heat deep portions of the body, such as the esophagus and the rectum. We therefore devised an electrode for radio frequency, and we have been successfully using this electrode in the treatment of both esophageal and rectal carcinomaThe 5 yr survival rates of patients with esophageal carcinoma, given either preoperative hyperthermochemoradiotherapy or chemoradiotherapy, were 43.2 and 14.7%, respectively. On the other hand, 11 patients with rectal carcinoma underwent radical surgery after preoperative hyperthermochemoradiotherapy. In the histologic studies of in the resected specimens, patients classified as marked, moderate, mild, and no effectiveness were seen in six, three, two, and zero cases, respectively. Since there were no severe side effects in patients given hyperthermia, this treatment deserves serious consideration when treating patients with malignant lesions in the esophagus or rectum.

ISSN:8756-0437    

DOI:10.1002/ssu.2980060104

出版商:John Wiley&Sons, Inc.    

年代:1990

数据来源: WILEY

摘要:

AbstractThe synergistic cytotoxicity of the combined treatment of hyperthermia and estradiol was demonstrated. This effect was measured for both clonogenic efficiency and membrane function, whose function was expressed as the initial rate of thymidine (dThd) incorporation. V‐79 cells in a suspension culture were simultaneously treated with 10−9‐10−4mg/ml estradiol at temperatures of 41–43°C in a water bath. The survival rate of the V‐79 cells decreased as the temperature increased. However, there was little decrease from treatment by estradiol alone. The survival rate for combined treatment by both heat and estradiol was lower than that of the separate treatment by either hyperthermia or estradiol alone, and the results were statistically significant. The values for Vmax(maximum reaction velocity) of hyperthermia decreased as the temperature increased, although the Vmaxvalue of estradiol treatment alone changed little. The I/Vmaxvalue for the combined treatment of heat and estradiol increased in comparison with that of heat treatment alone. However, the Km(Michaelis constant) value showed little correlation with the survival rate. Based on these results, we propose that estradiol enhances cell membrane damage by

ISSN:8756-0437    

DOI:10.1002/ssu.2980060105

出版商:John Wiley&Sons, Inc.    

年代:1990

数据来源: WILEY

摘要:

AbstractWe reviewed the clinical and pathologic experiences of gastric carcinoma cases seen in our department. Early diagnostics of the carcinomas were documented, especially in the cases of small gastric carcinoma, carcinoma of the gastric cardia, and in cases of young patients. The importance of lymphadenectomy in surgical treatment was emphasized as a cure for patients with gastric carcinoma. The surgical treatment and results for far advanced cases were also demonstrated. Several pathologic factors related to prognosis were shown; these included growth patterns, special gross or histologic types, stromal reactions, immunohistochemical studies, and others. We emphasize that a full understanding of the pathologic characteristics of gastric carcinoma is indispensable for providing adequate treatment.

ISSN:8756-0437    

DOI:10.1002/ssu.2980060106

出版商:John Wiley&Sons, Inc.    

年代:1990

数据来源: WILEY

摘要:

AbstractCytophotometric DNA analysis was performed on esophageal and gastric carcinomas. In 35 cases of mucosal and submucosal carcinoma of the esophagus, patients with types I and II (relatively regular in DNA distribution) had an uneventful postoperative course and no recurrence, whereas 3 of 15 (20%), and 5 of 9 (55.6%) with type III and type IV, respectively (widely scattered DNA distribution), died following a recurrence. Cytophotometric DNA analysis using biopsy specimens from 75 patients with esophageal cancer in various stages also showed a close relationship between the DNA distribution pattern and prognosis. However, the growth mode and the DNA ploidy of mucosal gastric cancer correlated well in the investigation of 66 cases. Thus, data of this method closely reflected the outcome in patients with digestive tract cancers. These results suggested the potential usefulness of cytophotometric DNA analysis for assessing the prognosis, even in the early stage of cancers.

ISSN:8756-0437    

DOI:10.1002/ssu.2980060107

出版商:John Wiley&Sons, Inc.    

年代:1990

数据来源: WILEY

摘要:

AbstractWe evaluated the applicability of limited hepatic resection in cases of hepatocellular carcinoma (HCC) in cirrhotic patients. According to the severity of impaired hepatocellular function, 37 patients underwent limited resection, and for 13, standard major hepatic resection was done. There were no significant differences in the mortality and survival rates between the two groups. This limited resection can be selectively used to treat cancer associated with cirrhosis and encapsulated tumorsFor further evaluation of this limited procedure, an attempt was made to elucidate the manner in which the surgical margin is linked to a recurrence after curative resection for hepatocellular carcinoma in patients with cirrhosis. Forty patients were divided into two groups; those in whom the margin from the cut surface to HCC in the fresh specimen was less than 10 mm wide [TW( + )] and patients in whom the surgical margin was equal to or exceeded 10 mm [TW( − )]. There were 24 and 16 patients in the TW( + ) and TW( − ) groups, respectively. There was no statistically significant difference in the rate of recurrence between the two groups. In patients with a tumor less than 4 cm in diameter, the extent of TW is not linked to an early recurrence. However, when the tumor size exceeds 4 cm, 10 mm of TW is inadequate to achieve curability. When a wide resection is not feasible, then adjuvant therapy should be aggress

ISSN:8756-0437    

DOI:10.1002/ssu.2980060108

出版商:John Wiley&Sons, Inc.    

年代:1990

数据来源: WILEY

摘要:

AbstractFor the chemosensitivity for carcinoma of digestive organs, gastric, colorectal, and hepatic cancer tissues were examined using in vitro succinate dehydrogenase inhibition (SDI) test and in vivo subrenal capsule (SRC) assay. The chemosensitivity varied in the tissue. The origin of an organ tumor, histological differentiation, and difference of primary or metastatic lesions are critical for determining chemosensitivity. Biochemical analysis shows that antitumor drugs have an increased susceptibility in tissues with high activity of pyrimidine nucleotide synthesis.

ISSN:8756-0437    

DOI:10.1002/ssu.2980060109

出版商:John Wiley&Sons, Inc.    

年代:1990

数据来源: WILEY

摘要:

AbstractWe prepared confluent monolayers of normal BALB/c 3T3 cells and compared differences in the growth of four types of cells superinoculated onto these nonirradiated and irradiated monolayers. The test cells were normal BALB/c 3T3 A31 cells, a squamous cell carcinoma from a human esophageal cancer (KSE‐1), human fetal fibroblasts, and V‐79 cells from Chinese hamster lung fibroblasts. Cell growth was checked by counting the cell number, determining [3H]thymidine incorporation and assessing colony formation. We found that on nonirradiated monolayers, colony formation of human fetal fibroblasts and normal BALB/c 3T3 cells was completely inhibited. On irradiated cells, test cells did exhibit some growth. KSE‐1 cells, which had a low clonogenic efficiency on plastic surfaces, formed colonies on both irradiated and nonirradiated cells. On these monolayers, the clonogenic efficiency of V‐79 cells was also higher than that on plastic surfaces. We conclude that the nonirradiated monolayer of BALB/c 3T3 cells completely inhibits the growth of superinoculated normal BALB/c 3T3 and human fetal fibroblasts, while on the other hand, they facilitate the growth of neoplastic KSE‐1 and V‐79 cells by providing a surface for cell adherence and growth, without affecting the presence of normal cells in

ISSN:8756-0437    

DOI:10.1002/ssu.2980060110

出版商:John Wiley&Sons, Inc.    

年代:1990

数据来源: WILEY

摘要:

AbstractLung cancer has considerable treatment problems, with a poor 5‐yr survival rate after surgery. Application of histopathological and immunohistopathological subtyping have proven to be powerful tools for the assessment of prognosis. Results in 33 patients with small cell carcinoma, 44 with large cell carcinoma, and five with adenoid cystic carcinoma of the lung are discussed. The 5‐yr survival rates in patients with small cell carcinoma of the oat cell type and intermediate type were 24 and 44%, respectively. Argyrophilic granules and neuron‐specific enolase, neuroendocrine markers, were detected more frequently in the oat cell type rather than in the intermediate type. In contrast, keratin, epithelial membrane antigen, and carcinoembryonic antigen, epithelial origin markers, were present more frequently in the intermediae type than in the oat cell type. The 5‐yr survival rates with large cell carcinoma of the compact growth type and the loose structure type were 46 and 28%, respectively, based on evidence of morphologically intercellular cohesion. The epithelial origin markers were detectable and more frequent in the compact growth type than in the loose structure type. The growth patterns of adenoid cystic carcinoma are classified as tubular, cribriform, and solid. The solid pattern was the most aggressive with extensive perineural invasion. We propose that the pathological properties of lung cancer should be examined as a prognostic implication of su

ISSN:8756-0437    

DOI:10.1002/ssu.2980060111

出版商:John Wiley&Sons, Inc.    

年代:1990

数据来源: WILEY