摘要:

Anthramycin methyl ether (AME) was tested for its ability to suppress erythropoiesis in the mouse. AME was injected either subcutaneously or intraperitoneally in doses ranging from 0.2 to 1.0 mg/kg. Radioiron was injected intravenously at varying times after AME and the 48-hour uptake in peripheral erythrocytes was determined. When subcutaneous injections were used, a threshold dose of greater than 0.2 mg/kg was required to reduce the uptake of radioiron. Maximum suppression was noted at 1.0 mg/kg AME. Intraperitoneal injections were more effective than subcutaneous ones; a maximum suppression was noted after 0.6 mg/kg. The nadir of radioiron incorporation was noted between 24 and 48 h after AME (1.0 mg/kg, s. c.) injection. Recovery required 10–12 days after which a slight overshoot above 59Fe incorporation in normal mice was observe

ISSN:0009-3157    

DOI:10.1159/000221241

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

In vitro studies of tobramycin showed it to be 2- to 4-fold more active than gentamicin against Pseudomonas species. 55 of 56 strains were inhibited by 2.5 μg of tobramycin/ml. Other gram-negative bacteria showed variable susceptibility to the drug. Strains of Staphylococcus aureus were generally inhibited by, and enterococci were generally resistant to 5 μg of tobramycin/ml. The effect of serum and of NaCl in the medium were studied. Combinations of tobramycin with carbenicillin gave conflicting results when examined for synergism against Pseudomonas by two different methods. Tobramycin failed to show synergism with penicillin against enterococc

ISSN:0009-3157    

DOI:10.1159/000221242

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

98 patients of all age groups were treated with the new broad-spectrum penicillin, amoxycillin (BRL 2333), for infections of the upper and lower respiratory tract, the urinary tract, otitis media and biliary tract infections. The product had to be discontinued in 5 cases because of side-effects; in 83 cases, there was a complete clinical resolution; and in 10 cases, there was a symptomatic improvement. Amoxycillin has showed its value as a routine antibiotic for the treatment ofbacterial infections in general practice.

ISSN:0009-3157    

DOI:10.1159/000221289

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Six rhinovirus serotypes showed in vitro susceptibility to two analogues (SK&F 21687 and SK&F 30097) of 3-substituted triazinoindole compounds. The intranasal SK&F 21687 medication did not prevent upper respiratory illness in 10 men who were challenged with rhinovirus type 44. No differences in the frequency and severity of clinical illness, virus shedding patterns, and serum and respiratory secretory antibody responses were detected between these drug-treated men and 10 placebo control subjects. The failure to affect the course of the illness may have been due to the insolubility of the test drug. Development of drug resistance by the virus was not demonstrated during the topical medication and the in vitro test.

ISSN:0009-3157    

DOI:10.1159/000221243

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The treatment of bacterial exacerbations of chronic bronchitis with amoxycillin offers several advantages. The antibiotic is well tolerated; it can be administered orally, achieving full activity at an economically favourable dosage; and it achieves a satisfactory resolution in the short term of the chronic bronchitic’s bacterial involvement, which, moreover, persists over a longer perio

ISSN:0009-3157    

DOI:10.1159/000221290

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The therapeutic effects of a number of antineoplastic agents administered subcutaneously to L1210 leukemic mice in silicone polymer (Silastic®, Dow Corning Medical Grade) implants is reported. 1-β-d-arabinofuranosylcytosine (ara-C, cytarabine), two 5′-acylates of ara-C (the 1-adamantanecarboxylate [AdO-ara-C] and acetate [AcO-ara-C]) and two nitrosoureas [l-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea {CCNU} and 1-(2-chloroethyl)-3-trans-4-methylcyclohexyl)-1-nitrosourea {MeCCNU}], when administered in this manner, significantly increased survival time and, in the case of ara-C, CCNU, and MeCCNU, resulted in a considerable number of cures. Silastic cylinders containing ara-C (625 mg ara-C/kg) implanted up to 3 days prior to tumor inoculation yielded significant therapeutic effects, suggesting that ara-C was being released at a slow rate such that cytotoxic levels of ara-C persisted in the mice for several days. This ‘depot’ effect was confirmed by studies of ara-C plasma levels and excretion after administration of 14C-ara-C in this manner. Silastic cylinders containing CCNU (25 mg CCNU/kg), when implanted 4 h prior to tumor inoculation showed activity, but no therapeutic effect was observed when administration was 24 h prior to inoculation. Studies in which drug implants were removed at various times after implantation indicated that the necessary exposure time (for optimum therapeutic effect) is considerably longer for an S-phase (DNA synthetic) specific agent such as ara-C than for nonphase-specific agents such

ISSN:0009-3157    

DOI:10.1159/000221244

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

100 patients suffering from chronic relapsing inflammatory diseases of the bronchopulmonary system were treated with amoxycillin (BRL 2333) for an average of 20 days. The efficacy of the product was noted and controlled from the clinical, radiographic, bacteriological and cytological aspects. The pathogenic organisms which were cultured from sputum and bronchial secretions belonged mostly to the group of problematic bacteria. Of 97 patients where complete control was possible, all showed a radiological and clinical satisfactory improvement on their original condition. In 59 cases, there was also a bacteriological cure. Cytologically, there was a significant improvement in 67% of the patients, but in 33 patients (of whom 28 had bronchial carcinoma), there was only a little improvement. The tolerance of amoxycillin per os was exceptionally good, and gastrointestinal disturbances were noted in only 2 patients. In the case of 3 patients, therapy had to be discontinued (in 2 cases because of allergy, and in 1 case because of a maculopapular exanthema).

ISSN:0009-3157    

DOI:10.1159/000221292

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The authors administered ethambutol (EMB) in doses of 25 mg/kg body weight daily for 2 months and 15 mg/kg body weight in another period to 55 patients of whom they have assessed only 50. These are patients who could be followed up for at least 3 months. 46 of them had pulmonary tuberculosis, 2 basilar meningitis, 1 tuberculosis of bones and joints and 1 specific adnexitis. Patients were in question whose common feature lay in difficult curability owing to the resistance of tubercle bacilli (48%), hepatic lesion (63%), intolerance of drugs (50%) and serious superposed diseases (46%). EMB was combined with one or two efficient drugs that could be applied. Therapeutic results were assessed in all patients whose therapy lasted at least 4 months (4–21 months, average 8 months). Patients who excreted tubercle bacilli were rendered negative. Negativity was obtained sooner if the drug combination contained RAMP. Radiologically, once aggravation of the cavernous process ensued. EMB was discontinued once after 14 days and once after 21 months of treatment owing to increasing values of the liver function tests. The first woman patient had had epidemic hepatitis and showed an allergic reaction to SM and VM, the other patient recovered from a severe hepatic lesion with icterus after MZA. The treatment was twice interrupted for fear of a possible damage to sight after degenerative alterations had been ascertained on the eyeground after 2 and 4 months of therapy but they did not fall within the aspect of retrobuloar Walsh’s neuritis. Tolerance of EMB was very good, no subjective troubles were ascertai

ISSN:0009-3157    

DOI:10.1159/000221245

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Ten cases of urinary tract infections were treated with amoxycillin in a dosage of 3 times 375 mg (orally) for 10 days. The treatment was successful in nine cases. The laboratory control was done before commencement of the treatment, at the end and one month later. The serum concentrations in all patients as well as the quantity excreted in the urine were determined 1, 2, 4 and 6 h after the administration of the antibiotic. None of these cases presented any side-effects.

ISSN:0009-3157    

DOI:10.1159/000221293

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The present paper reports clinical and pharmacological studies with amoxycillin in the treatment of urinary tract infection. 35 elderly hospitalised patients were treated. Their altered general condition due to underlying diseases explains our moderate success rate (45, 7%). The oral dosage ranged from 1, 5–2, 25 g daily. A maximum serum level of ± 6 μg/ml was observed 2 h after oral administration of 750 mg. This level was ± 4, 5 μg/ml 4 h after oral administration of 500 mg amoxyc

ISSN:0009-3157    

DOI:10.1159/000221294

出版商:S. Karger AG    

年代:1973

数据来源: Karger