Reported alcohol and tobacco (ie, cigarette) use of 214 Hispanic migrant adolescents enrolled in the National Migrant Education Program in San Diego County was obtained. Level of acculturation was found to be related to alcohol use, ie, acculturated females had more drinks in their lifetime, and more acculturated males and females were more likely to binge drink in the last 30 days. In contrast to previous reports with Hispanic adults, acculturation was not related to cigarette use in this population of adolescents. Focus groups were conducted with migrant adolescents and parents in an effort to assess the need for alcohol and tobacco use prevention programs, and identify methods for their implementation if needed.