Tumor Markers in Hypertensive Disorders of Pregnancy
作者:
H. Schröcksnadel,
G. Daxenbichler,
E. Artner,
G. Steckel-Berger,
O. Dapunt,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1993)
卷期:
Volume 35,
issue 4
页码: 204-208
ISSN:0378-7346
年代: 1993
DOI:10.1159/000292701
出版商: S. Karger AG
关键词: Preeclampsia;Tumor marker;TPA
数据来源: Karger
摘要:
Plasma levels of tumor markers (CEA, TPA, CA 15.3, CA 125, α-fetoprotein) for 50 patients with hypertensive disorders of pregnancy were compared with those of 50 healthy women with singleton pregnancies and 50 healthy non-pregnant controls. With the exception of CEA all tumor marker values were higher in pregnant women, these differences being statistically significant (all p < 0.0001). Alpha-fetoprotein was lower in hypertensive than in healthy pregnant women (p = 0.0004), whereas CEA, CA 15.3 and CA 125 showed no statistically significant differences. TPA values in patients with hypertensive disorders of pregnancy (median 190 U/l) were 2.7 times higher than those of healthy pregnant controls (median 70.5 U/l) with a statistically significant difference (p < 0.0001). The individual degrees of disease severity demonstrated increasing TPA medians (pregnancy-induced hypertension: 106.5 U/l; pre-eclampsia: 200 U/l; HELLP syndrome: 339 U/l). TPA levels correlated positively with clinical severity of disease and negatively with fetal (rS = –0.58; p < 0.0001) and placental weight (rS = –0.44; p = 0.01).
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