Two computations in a series of ongoing studies on prediction of success in a collegiate program of nursing are reported. In both studies, results obtained via product moment and multiple regression analyses demonstrated that collegiate nursing grade point average (GPA) could be predicted using 20 or even five predictors, but prenursing (freshman and sophomore) GPA emerged as the significant variable in overall prediction. In the data presented first, 56 intellective, interest, personality, and educational varibales were examined as potential GPA predictors on two independent student samples. The data in the second study used 55 variables (omitting the prenursing GPA). Under cross-validation, in the study discussed first, the best five predictors manifested only minimal predictive shrinkage, and prenursing GPA clearly emerged as the single most significant predictor; in the second study, when prenursing GPA was deleted from the prediction matrix, considerable prediction shrinkage occurred, revealing that prenursing GPA clearly was a significant factor in overall prediction.