Action of Dinitrophenol and Lanatoside C on the Canine Heart‐Lung Preparation
作者:
E. Rothlin,
M. Taeschler,
A. Cerletti,
期刊:
Circulation Research
(OVID Available online 1955)
卷期:
Volume 3,
issue 1
页码: 32-38
ISSN:0009-7330
年代: 1955
出版商: OVID
数据来源: OVID
摘要:
Dinitrophenol (DNP) induces failure of the canine heart-lung-preparation and increases specifically its O2-consumption. Lanatoside C compensates this failure as long as the degree of dinitrophenol poisoning is moderate and the O2-supply sufficiently ample. This cardiac glycoside does not influence the metabolic action of dinitrophenol, i.e. the increased O2-consumption, nor does it counteract the failure due to a large degree of dinitrophenol poisoning. From these findings the mechanism of action of Lanatoside C is discussed.
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