In this article the authors encourage counselors and other human development professionals to provide HIV (human immunodeficiency virus) and AIDS (Acquired Immune Deficiency Syndrome) prevention programming that is sensitive to the social and cultural contexts of the specific group(s) addressed. The focus is on four groups that have been both the target for societal oppression and dramatically affected by the HIV and AIDS epidemic: women, gay and bisexual men, African Americans, and Latinos. First, information is provided to help professionals become more aware of the social and cultural contexts of behavior related to HIV and AIDS prevention in the four groups named. Second, four recommendations are made to assist professionals to sensitively apply that awareness to the planning and implementing of HIV and AIDS prevention programming. Four exemplar programs illustrate the implementation of these recommendations.