EXPERMIMENTAL AMYLOIDOSIS INDUCED BY 20‐METHYLCHOLANTHRENE IN RABBITS†
作者:
Fumio Hirao,
Tomoo Fujisawa,
Eiro Tsubura,
Yasuyuki Akamatsu,
Yuichi Yamamura,
期刊:
Pathology International
(WILEY Available online 1967)
卷期:
Volume 17,
issue 1
页码: 23-35
ISSN:1320-5463
年代: 1967
DOI:10.1111/j.1440-1827.1967.tb01200.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
In the course of repeated intrabronchial application of 20‐methylcholanthrene to the rabbits, many of them were found to die from uremia with nephrotic syndrome. Approximately 60 % of animals, 3 months or longer under the experiment, showed swollen kidneys with the glomerular tufts deposited with amyloid and tubules dilated with hyaline casts. These lesions in the kidneys as well as in the liver, spleen and adrenals seen in 24 rabbits were consistent with systemic amyloidosis. Autofluorescence similar to that of 20‐methylcholanthrene was observed in the unstained frozen sections of the kidney at the site of amyloid deposition. Amyloidosis developed only in one rabbit of each group which received either intrabronchial application of 4‐nitroquinoline N‐oxide or intravenous administration of 20‐methylcholanthrene. Experimental procedures for inducing amyloidosis and pathogenesis of experimental amyloidosis were
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