The human dermoepidermal anchoring fibrils, the oxytalan fibers, and the elaunin fibers have been related with dermoepidermal adherence. In the present work their ultrastructure and origin are studied. The similarity between the segment long-spacing tropocollagen molecular aggregates and the anchoring fibrils band patterns is evidenced. This fact supports the concept that the anchoring fibrils may be formed by a mechanism of side by side tropocollagen molecular aggregation after its polar binding to the basement lamina. The oxytalan fibers were studied in the superficial dermis, and their direct continuity with the elaunin fibers was demonstrated. The role of these fibers in the dermoepidermal mechanical adhesion is discussed.