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Onset of the Vasoconstrictor Effect of Diflucortolone Valerate, Betamethasone Valerate, and Fluocinolone Acetonide Ointments Applied for Varying Periods under Occlusive Dressings

 

作者: J. Szadurski,   F. Renz,   D. Gasser,  

 

期刊: Dermatology  （Karger Available online 1976）
卷期: Volume 153, issue 4  

页码: 236-242

 

ISSN:1018-8665

 

年代: 1976

 

DOI:10.1159/000251062

 

出版商: S. Karger AG

 

关键词: Topical corticoids;Diflucortolone valerate ointment;Betamethasone valerate ointment;Fluocinolone acetonide ointment;Vasoconstrictor effect (onset);Occlusive dressing;Application time

 

数据来源: Karger

 

摘要:

Evaluation of cutaneous vasoconstriction after applications of varying duration of topical corticoids on the flexor surfaces of the forearms of 20 patients with intact skin shows a significantly faster blanching effect with diflucortolone valerate ointment than with fluocinolone acetonide and betamethasone valerate ointments. Furthermore, the test shows that even for a highly active preparation, such as the diflucortolone valerate ointment, an application time of less than 3 h only exceptionally leads to vasoconstriction in the healthy skin.

 

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