Disseminated Porokeratosis Mibelli Treated with RO 10-9359
作者:
Silvana Bundino,
Alberto Maria Zina,
期刊:
Dermatology
(Karger Available online 1980)
卷期:
Volume 160,
issue 5
页码: 328-336
ISSN:1018-8665
年代: 1980
DOI:10.1159/000250514
出版商: S. Karger AG
关键词: Porokeratosis Mibelli;Treatment;Retinoids
数据来源: Karger
摘要:
2 patients with widespread porokeratosis Mibelli (PM) were treated orally with RO 10-9359. The dose was 75 mg/day for 10 days, then 50 mg/day for 3 weeks. The drug produced a good improvement of condition with no serious side effect. Ultrastructural examination of a healed lesion showed the presence of a fine granular substance in the intercellular space of the spinous layer, most likely produced by keratinocytes; ultrastructural cellular alterations of PM were still evident and the lesion recurred after suspension of treatment.
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