Results are presented on 3 Amerindian populations of interior French Guiana: the Emerillon, the Wayampi and the Wayana. Blood specimens were examined for the red cell antigens A, A1 B, H, M, N, S, s, P1, C, D, E, c, e, C, K, k, Kpa, Kpb, Jsb, Lea, Leb, Lex, Fya, Fyb, Jka, Dia, I, Xga. The frequencies found are within the range of those previously reported in other Amerindian populations, except for the Diego system, where the Dia gene frequencies are among the highest observed.