This study compared the training heart rate and oxygen uptake (±O2) computed from commonly used exercise prescription methods with heart rate, ±O2, and rate of perceived exertion (RPE) that corresponds to the gas exchange anaerobic threshold (ATge) in three groups. The three groups were composed of 25 patients with cardiac disease taking beta-adrenergic receptor blocking agents (BB), 25 patients not taking beta-blockers (NBB), and 25 younger healthy individuals. The training heart rate was computed using 70% heart rate reserve, 70% maximal heart rate, and 85% maximal heart rate. The training ±O2was computed using 57% maximum oxygen uptake (±O2max) and 78% ±O2max. For the total group, all three methods computed training heart rates that differed from the heart rate at ATge (P < 0.01). The smallest difference from heart rate at ATge resulted using the 70% maximal heart rate method (6 beats/min). Both methods for computing training ±O2resulted in values that were significantly different (P < 0.05) from the ±O2at the ATge. Using 57% ±O2maxresulted in a difference of 0.79 mL/kg-1. There were no between-group differences for the RPE at the anaerobic threshold (11.0 ± 2.1 for the total group). Recalculating each prescription method so the training heart rates and ±O2did not differ from the ATge values resulted in using 52.8% heart rate reserve, 74.3% maximal heart rate, and 61.7% ±O2max.