Serum Levels of Ritodrine during Oral Maintenance Therapy
作者:
D.A. Smit,
G.G.M. Essed,
J. de Haan,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1984)
卷期:
Volume 18,
issue 2
页码: 105-112
ISSN:0378-7346
年代: 1984
DOI:10.1159/000299058
出版商: S. Karger AG
关键词: Ritodrine;Plasma level
数据来源: Karger
摘要:
In order to elucidate some aspects of the efficacy of orally administered ritodrine, serum concentrations of ritodrine were determined during intravenous and oral therapy. Ritodrine serum concentrations during steady-state intravenous therapy (200 μg/min) ranged from 91.0 to 123.0 ng/ml. Serum concentrations during maintenance therapy with 120 mg ritodrine per os fluctuate between 3.2 and 30.5 ng/ml, depending on the moment of tablet intake. During oral maintenance therapy a striking correlation was found between the maternal heart rate and the serum concentration of ritodrine. The findings suggest that efficacy of orally administered ritodrine is doubtful on pharmacological grounds.
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