AbstractThe aqueous extract of stem bark ofMoriga pterygosperma(Family Moraingaceae) was investigated for its effect on various pharmacological parameters. In cardiovascular profile at lower concentrations (1–10 ng) it produced a dose dependent positive inotropic effect (n= 3, 1.29 ± 0.021 for 10 ng) and at higher concentrations (0.1–1 μg) a dose dependent negative inotropic effect (n= 3, 0.53 ± 0.033 for 1 μg) on the isolated frog heart. It also produced a dose dependent hypotensive effect on dog blood pressure (n= 3, 82 ± 0.98 for 20 mg/kg). It failed to elicit any effect on isolated guinea‐pig ileum, rat stomach fundus or frog rectus abdomi