Treatment of Respiratory Infections with Fosfomycin
作者:
R. Bacardí,
J. Tornos,
I. Moga,
N. Martí,
P. Alomar,
L. Gaztelurrutia,
C. Villalonga,
期刊:
Chemotherapy
(Karger Available online 1977)
卷期:
Volume 23,
issue 1
页码: 343-347
ISSN:0009-3157
年代: 1977
DOI:10.1159/000222074
出版商: S. Karger AG
关键词: Fosfomycin;Bronchopneumopathies
数据来源: Karger
摘要:
Results are presented for a series of 29 patients, 14 males and 15 females, with serious respiratory infections, in which fosfomycin proved effective. In all cases the study was completed by bacteriological, clinical, radiological and analytical controls. The average dose was 6 g/day (3 g orally and 3 g intramuscularly) for 1 or 2 weeks. The flor isolated were P. aeruginosa, E. coli, Klebsiella-Enterobacter and D. pneumoniae. Overall sensitivity percentages were best for fosfomycin, gen-tamicin and colistin. Of the 29 germs isolated, only one strain of P. aeruginosa became resistant: this represents 3% resistance development. No side effects of intolerance or signs of hepatorenal insufficiency were observed during the treatment. Of the 29 patients treated, 22 were clinically cured, denoting 76% success.
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