Ascitic versus Solid Growth of Ehrlich Ascites Tumor Influenced by Immunological Factors
作者:
F. Čulo,
N. Allegretti,
M. Marušić,
期刊:
Oncology
(Karger Available online 1978)
卷期:
Volume 35,
issue 1
页码: 15-21
ISSN:0030-2414
年代: 1978
DOI:10.1159/000225248
出版商: S. Karger AG
关键词: Tumor growth;Immunotherapy;Tumor immunisation;Ehrlich ascites
数据来源: Karger
摘要:
A certain number of CBA mice injected intraperitoneally with 1 × 106 or fewer Ehrlich ascites tumor (EAT) cells did not develop ascites tumors but solid tumors at the inoculation site. The incidence of solid tumors proved dependent on the level of immunological reactivity of recipients, being increased in mice with increased immunological potency and absent in mice in which this potency was reduced. Mice bearing solid tumors had increased level of cytotoxic antitumor antibodies in serum. Possible reasons for a greater immune resistance of cells growing in subcutaneous tissue, than in the abdominal cavity, are discussed
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