Effect of Superoxide Dismutase on Liver Ischemia-Reperfusion Injury in the Rat: A Biochemical Monitoring
作者:
F. Romani,
M. Vertemati,
M. Frangi,
P. Aseni,
R. Monti,
A. Codeghini,
L. Belli,
期刊:
European Surgical Research
(Karger Available online 1988)
卷期:
Volume 20,
issue 5-6
页码: 335-340
ISSN:0014-312X
年代: 1988
DOI:10.1159/000128783
出版商: S. Karger AG
关键词: Ischemia;liver;Reperfusion injury;Oxygen radicals;Superoxide dismutase;Liver function test;ATP tissue level
数据来源: Karger
摘要:
Oxygen free radicals have been implicated in the pathogenesis of postischemic liver injury. High-dose superoxide dismutase (SOD), a radical scavenging enzyme, has been investigated in a rat model of liver ischemia reperfusion by biochemical monitoring. Blood vessels to the median and left lobe were clamped for 1 h and then reperfusion was allowed. The indices used were serial venous blood levels of AST, ALT, calcium, and ATP determination in liver tissue. In SOD-treated animals (7,5000 U i.v.) a significant attenuation of the rise in enzyme levels was observed as well as the absence of the decrease in calcium level in the early phase after reperfusion as compared with control rats, and furthermore ATP restoration was significantly increased.
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