Immune Function in Adult C57BL/6J Mice Following Exposuke to Ukethan Pre-OK Postnatally
作者:
LuebkeRobert W.,
RiddleMarie M.,
RogersRonald R.,
RoweDenise G.,
GarnerR. John,
SmialowiczRalph J.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1986)
卷期:
Volume 8,
issue 2
页码: 243-257
ISSN:0892-3973
年代: 1986
DOI:10.3109/08923978609028617
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractAdministration of urethan (LTRE or ethyl carbamate) to mice results in the development of a variety of tumors, and, in certain strains of mice, marked suppression of the immune response. Perinatal exposure of mice to URE has been found to result in increased tumor induction compared to exposure of adult animals. In the present study, the effects of perinatal exposure to UKE on the development of immunorompetence was investigated. Pregnant mice were injected with total doses of either 0.5 or 1.0 mg URE/g of body weight over days 7–16 of gestation or pups of nontreated dams were administered a total dose of 2.0 mg URE/g of body weight over postpartum days 5–14. Postnatal exposure to URE suppressed NK (natural killer) cell activity but left intact other measured parameters of the host defense system. Prenatal exposure, on the other hand, resulted in elevated leukocyte counts and a trend toward increased spleen and thymus size in offspring of treated mothers. Humoral immune function, as measured by the IgM response to sheep erythrocytes, was suppressed in pups from dams injected with a total of 1.0 mg/g URE. These results indicate that marked differences in immunopharmacologic effects may be observed if chemical exposure occurs at different times during the ontogeny of the immune system.
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