Autoimmunity to collagen in adult periodontal disease: Immunoglobulin classes in sera and tissue
作者:
O. Anusaksathien,
G. Singh,
N. Matthews,
A. E. Dolby,
期刊:
Journal of Periodontal Research
(WILEY Available online 1992)
卷期:
Volume 27,
issue 1
页码: 55-61
ISSN:0022-3484
年代: 1992
DOI:10.1111/j.1600-0765.1992.tb02086.x
出版商: Blackwell Publishing Ltd
关键词: collagen;periodontal disease;autoimmunity;classes
数据来源: WILEY
摘要:
The immunoglobulin class distribution of antibody to human collagen type I has been examined in sera and gingival extracts from patients with adult chronic periodontitis. Tissue extracts were made either by simple washing or ultrasonication. With either method, IgG and IgA antibodies to collagen were present in higher concentration in tissue extracts than in autologous serum when adjustment was made for dilution differences. No significant differences were found for IgM antibodies. Antibodies to human collagen type I are usually “natural antibodies” of the IgM class and, therefore, our findings suggest a class switch to IgG in inflamed gingivae, presumably due to prolonged antigenic stimulat
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