In vitroandin vivostudies on capsaicin and membrane bound calcium interactions in the rat lung using chlorotetracycline (CTC) as a fluorescence probe
作者:
Amit Krishna De,
Jagat Jiban Ghosh,
期刊:
Phytotherapy Research
(WILEY Available online 1991)
卷期:
Volume 5,
issue 1
页码: 5-8
ISSN:0951-418X
年代: 1991
DOI:10.1002/ptr.2650050103
出版商: John Wiley&Sons, Ltd.
关键词: Capsaicin;mitochondria;microsome;calcium influx
数据来源: WILEY
摘要:
AbstractChlorotetracycline calcium fluorescence studies have been carried out on acute and chronic capsaicin treated rat lung mitochondria and microsome membrane fractions in the presence of different concentrations of capsaicin (1–100 nM) underin vivoconditions. Results indicate, that acute capsaicin treated rat lung membrane fractions are quite different from those that are chronically treated, with respect to capsaicin mediated calcium permeability, measured in terms of calcium induced CTC fluorescence alterations. It seems that the reported ‘activation’ phenomena of acute capsaicin treatment may be associated with calcium influx across the membrane. On the other hand, the reported ‘desensitization’ phenomena of chronic capsaicin treatment may be due to inhibition of capsaicin mediated calci
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