The human immunodeficiency virus (HIV) causes a chronic, progressive, immune deficiency disease, the most severe phase of which is Acquired Immune Deficiency Syndrome (AIDS). HIV is a newly characterized human retrovirus transmitted only by direct exposure to blood or blood derivatives, certain acts of sexual intercourse, or transfer from infected mother to fetus or infant. In this article the author reviews the most important current epidemiologic, clinical, and virologic information about HIV and HIV disease and provides a factual framework for understanding the issues created by the epidemic.