The Rat Gastric Phospholipids: Increased in Ulcerated Mucosa and Decreased after Healing
作者:
B.S. Dunjić,
I. Svensson,
J. Axelson,
P. Adlercreutz,
A. Ar’Rajab,
S. Bengmark,
期刊:
European Surgical Research
(Karger Available online 1993)
卷期:
Volume 25,
issue 6
页码: 376-382
ISSN:0014-312X
年代: 1993
DOI:10.1159/000129304
出版商: S. Karger AG
关键词: Lysophosphatidylcholine;Sphingomyelin;Phosphatidylcholine;Phosphatidylinositol;Phosphatidylethanolamine;Fatty acids;Rat;Gastric mucosa;Chronic ulcer;Indomethacin
数据来源: Karger
摘要:
The composition and content of the gastric phospholipids were followed during development and healing of indomethacin-induced chronic, antral ulcers in rats. The individual phospholipids were identified by thin-layer chromatography and quantitatively estimated by spectrophotometric analysis of phosphate. No changes were found in phospholipid composition and content after a 24-hour fast or during the first 24 h after indomethacin was given. The total phospholipid content and the content of lysophosphatidylcholine and phosphatidylcholine were increased on the 5 th day, when chronic ulcers were established. After 4 weeks, when the ulcers were healed, the total phospholipid content, and content of phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol, respectively, were decreased, while the content of lysophosphatidylcholine was increased. In conclusion, the composition and content of gastric phospholipids were altered in rats with ulcers as well as in rats with healed ulcers.
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