The Effect of p-Chloroaniline on Leucocytes of Sheep Peripheral Blood Under the Migration-Inhibition Test Conditions
作者:
KačmárP.,
PistlJ.,
MikulaI.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1995)
卷期:
Volume 17,
issue 3
页码: 577-584
ISSN:0892-3973
年代: 1995
DOI:10.3109/08923979509016388
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractToxic and immunotoxic effects of p-chloroaniline-a metabolite of herbicide monolinuron-were investigated in peripheral blood leucocytic suspensions of five sheep using a migration-inhibition test. The toxic effect of p-chloroaniline was recorded at concentrations 1.0 to 0.1 mg.ml−1and the immunotoxic one at concentrations 0.01-0.001 mg.l−1. The toxic effect was demonstrated by total inhibition of leucocyte migration. The immunotoxic effect, determined as mitogenic activation of leucocytes by phytohemagglutinine, concavaline A and lipopolysaccharide, was detected at 10 to 100-fold lower concentrations of p-chloroaniline than those which resulted in toxic effects.
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