Contact Allergy as a Therapeutic Tool for Alopecia Areata: Application of Squaric Acid Dibutylester
作者:
R. Happle,
K.J. Kalveram,
U. Büchner,
K. Echternacht-Happle,
W. Göggelmann,
K.-H. Summer,
期刊:
Dermatology
(Karger Available online 1980)
卷期:
Volume 161,
issue 5
页码: 289-297
ISSN:1018-8665
年代: 1980
DOI:10.1159/000250380
出版商: S. Karger AG
关键词: Alopecia areata;Therapy;Contact allergy;Squaric acid dibutylester;Skin testing in guinea pigs;Bacterial plate incorporation assay;Ames test
数据来源: Karger
摘要:
Squaric acid dibutylester (SADBE), a potent contact allergen, was tested for mutagenicity in the bacterial plate incorporation assay (Ames test), in the presence and absence of mammalian microsomes. In contrast to dinitrochlorobenzene which is mutagenic in this test, SADBE was found not to be mutagenic. In 53 patients with extensive or total alopecia areata, SADBE dissolved in acetone was applied weekly to one side of the head, the other side serving as control. In 46 patients (87%), hair regrew either exclusively on the treated side, or considerably faster and denser on this side. In some patients, continuous treatment failed to maintain the response. Persistent response was observed in 37 patients (70%). These results are essentially the same as those obtained with DNCB. Therefore, contact allergy is proposed as a therapeutic concept for alopecia areata.
点击下载:
PDF
(1923KB)
返 回