Plasma volume changes during hypoglycaemia: the effect of autonomic blockade
作者:
J. HILSTED,
H. FRANDSEN,
N.J. CHRISTENSEN,
S.L. NIELSEN,
期刊:
European Journal of Clinical Investigation
(WILEY Available online 1991)
卷期:
Volume 21,
issue 1
页码: 22-26
ISSN:0014-2972
年代: 1991
DOI:10.1111/j.1365-2362.1991.tb01353.x
出版商: Blackwell Publishing Ltd
关键词: Catecholamines;haematocrit;hypoglycaemia;insulin;plasma volume
数据来源: WILEY
摘要:
Abstract.To investigate the role of the autonomic nervous system in changes in blood volume and composition induced by acute hypoglycaemia in man, seven healthy subjects participated in three experiments on separate days: insulin‐induced hypoglycaemia with concomitant α‐adrenoceptor blockade; insulin‐induced hypoglycaemia with total autonomic blockade (α‐adrenoceptor blockade combined with β‐adrenoceptor blockade and atropine); and insulin‐induced hypoglycaemia without any autonomic blockade. In the experiments without autonomic blockade the peripheral venous hematocrit increased, plasma volume decreased, intravascular albumin content decreased and the transcapillary escape rate of albumin increased. In both experiments with autonomic blockade the increase in venous haematocrit was abolished, yet plasma volume decreased, intravascular albumin content decreased and the transcapillary escape rate of albumin increased in these experiments. Thus, the changes in plasma volume and composition in response to hypoglycaemia are due to the combined actions of adrenaline
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