A Study on Anti-Inflammatory and Peripheral Analgesic Action ofSalvia sclareaOil and Its Main Components
作者:
MarioD. L. Moretti,
AlessandraT. Peana,
Margherita Satta,
期刊:
Journal of Essential Oil Research
(Taylor Available online 1997)
卷期:
Volume 9,
issue 2
页码: 199-204
ISSN:1041-2905
年代: 1997
DOI:10.1080/10412905.1997.9699459
出版商: Taylor & Francis Group
关键词: Salvia sclarea;Lamiaceae;essential oil composition;methyl chavicol;linalool;α-terpineol;linalyl acetate;anti-inflammatory effect;analgesic effect
数据来源: Taylor
摘要:
Activity against the acute inflammatory process induced by carrageenin and histamine in rats and the anti-nociceptive effect in mice were investigated after administration ofSalvia sclareaoil and some of its constituents. The oil showed a significant anti-inflammatory effect and moderate analgesic action after subcutaneous injection at a dose of 250 mg/kg. The anti-inflammatory action was more conspicuous in the carrageenin-induced edema, where it produced the equivalent effect of a 5 mg/kg dose of indomethacin, than in the histamine-induced edema. The effect was correlated to the presence of methyl chavicol, linalool, α-terpineol and linalyl acetate. The results show that these constituents produce less anti-inflammatory action when administered separately than the oilin toto, and are also less effective than the oxygenated fractions obtained by Flash chromatography of the oil. This indicates that the action of the oil is determined by synergistic action of its constituents. The moderate peripheral analgesia (evaluated by writhing test) produced byS. sclareaoil appears to be mainly attributable to its alcoholic component.
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