The use of a direct liquid introduction probe with a short guard column as the method of sample introduction is explored. This technique is an alternative to the conventional direct probe method. The method is rapid, involatile compounds can be analyzed, and volatile compounds are not lost in the vacuum lock. Screening for trichlorophenol in urine, by observing the loss of [M-HCOCI]+, is used to test the technique. The advantages and disadvantages of split and splitless direct liquid introduction probes and column concentration are discussed. Detection limits in the low nanograms were observed, and samples may be analyzed every 30 seconds.