REVERSAL OF SOME THERAPEUTIC EFFECTS OF AN ANTIPSYCHOTIC AGENT BY AN ANTIPARKINSONISM DRUG
作者:
MAN SINGH,
JAMES SMITH,
期刊:
The Journal of Nervous and Mental Disease
(OVID Available online 1973)
卷期:
Volume 157,
issue 1
页码: 50-58
ISSN:0022-3018
年代: 1973
出版商: OVID
数据来源: OVID
摘要:
Data are presented from a multidimensional, longitudinal study in 10 acute schizophrenics which indicate that the addition of benztropine to haloperidol reversed the course of some of the therapeutic changes. The nontherapeutic interaction was selective involving what may be called social avoidance behavior but not the cognitive integrative dysfunctions. It is suggested that neuroleptic effects on social avoidance behavior in schizophrenics may be mediated through a cholinergic system. Caution is advised against routine use of antiparkinsonism agents with neuroleptics.
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