Free Drug Levels Monitoring as a Detector of False Metabolic Refractory Epilepsy
作者:
M. Gianelli,
S. Gentile,
L. Verzè,
U. Dimanico,
M. Baruchello,
F. Monaco,
R. Mutani,
期刊:
European Neurology
(Karger Available online 1988)
卷期:
Volume 28,
issue 6
页码: 349-353
ISSN:0014-3022
年代: 1988
DOI:10.1159/000116300
出版商: S. Karger AG
关键词: Carbamazepine;Phenobarbital;Free levels;Refractory epilepsy
数据来源: Karger
摘要:
Unbound and total plasma levels of carbamazepine (CBZ) and phenobarbital (PB) were evaluated in a group of 12 refractory patients out of 397 subjects, with normal values of total drug concentration and unbound levels below the expected ones. We established a minimal acceptable ‘subtherapeutic’ free drug level, i.e. <9.62 µg/ml for PB and 1.36 µg/ml for CBZ. PB and CBZ dosages were increased during a 3-month period. We observed a normalization of free levels, unaccompanied by a significant decrease in seizure frequency. Free drug level monitoring may prove to be an unchallenged detector of false metabolic refractory epi
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