Release of 17-Beta-Oestradiol from a Vaginal Ring in Postmenopausal Women: Pharmacokinetic Evaluation
作者:
Günther Schmidt,
Sven-Börje Andersson,
Örjan Nordle,
Carl-Johan Johansson,
Per Olov Gunnarsson,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1994)
卷期:
Volume 38,
issue 4
页码: 253-260
ISSN:0378-7346
年代: 1994
DOI:10.1159/000292492
出版商: S. Karger AG
关键词: 17β-Oestradiol;Vaginal ring;Controlled release;Pharmacokinetic evaluation
数据来源: Karger
摘要:
Oestrogen-containing vaginal rings of various designs have been utilised in hormone replacement therapy. In contrast to the traditional ‘homogeneous’ design, rings designed with a steroid-containing core and outer polymer sheath provide a diffusion-controlled release rate which enables the delivery of low doses of drug. The aim of this investigation was to evaluate in vitro oestradiol release from a ‘core’ designed vaginal ring (Estring®) and furthermore, to establish the in vivo concentration-time course of oestradiol, oestrone and total oestrone (unconjugated plus conjugated) in consecutive applications of such an oestradiol-containing vaginal ring in postmenopausal women. Results indicate that the controlled release design of Estring® produces stable, low systemic plasma concentrations of oestradiol and has an extended time period of release.
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