Reduced Glomerular Filtration and Elevated Urinary Protein Excretion in Diabetic Ketoacidosis
作者:
M. MILTÉNYI,
A. SZABÓ,
T. TULASSAY,
A. KÖRNER,
E. KENESEI,
M. DOBOS,
期刊:
Acta Pædiatrica
(WILEY Available online 1990)
卷期:
Volume 79,
issue 4
页码: 444-447
ISSN:0803-5253
年代: 1990
DOI:10.1111/j.1651-2227.1990.tb11491.x
出版商: Blackwell Publishing Ltd
关键词: GFR in diabetic ketoaeidosis;tubular dysfunction in IDDM
数据来源: WILEY
摘要:
ABSTRACT.Glomerular filtration rate (GFR) was measured by two methods in 9 children with diabetic ketoacidosis (DKA), directly by true creatinine clearance and indirectly by means of serum beta‐2‐microglobulin levels. We found significantly reduced GFR in the first hours of DKA. The rapid improvement in GFR after fluid and electrolyte replacement indicates that volume depletion is the major cause of low filtration rate. In spite of the reduced GFR we observed pronounced albuminuria and low molecular weight (LMW) proteinuria. We conclude that the pathological albuminuria and microalbuminuria in DKA are caused not by glomerular hyperfiltration but by tubular dysfunc
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