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In vivo Attachment ofStreptococcus pneumoniaeandHaemophilus influenzaeto Nasopharyngeal Epithelium in Children

 

作者: Lars-Eric Stenfors,   Simo Räisänen,  

 

期刊: ORL  (Karger Available online 1992)
卷期: Volume 54, issue 1  

页码: 25-28

 

ISSN:0301-1569

 

年代: 1992

 

DOI:10.1159/000276254

 

出版商: S. Karger AG

 

关键词: Bacterial adherence;Inflammation;Acridine orange;Fluorescence microscopy;Otitis media;Immunoglobulins

 

数据来源: Karger

 

摘要:

Attachment of Streptococcus pneumoniae and Haemophilus influenzae to epithelial cells on the posterior wall of the nasopharynx (NPH) was determined in 10 healthy children, culture-positive for either of these microorganisms. By using immunofluorescence technique and specific fluorescein-labelled antisera against these microorganisms, it was shown that in only 2 of the children studied were these pathogens firmly attached to the non-ciliated cells of the NPH. Attachment of S. pneumoniae and H. influenzae to the epithelial cells close to the nasopharyngeal opening of the Eustachian tube is of the utmost importance for the development of invasive disease, especially acute otitis media. Attachment of these pathogens to the epithelial cells covering the adenoid tissue may naturally be of significance for the induction of specific antibody production against these microorganisms.

 

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