Oral Administration of Idarubicin as First Line Cytostatic Therapy in Patients with Metastasized Breast Cancer and Favourable Prognosis
作者:
K. Possinger,
H. Wagner,
P. Worst,
W. Queißer,
K. Bremer,
K. Rieche,
M. Klee,
M. Westerhausen,
R. Donhuijsen-Ant,
D. Fritze,
L. Edler,
G. Stiegelbauer,
K. Burk,
期刊:
Onkologie
(Karger Available online 1991)
卷期:
Volume 14,
issue 1
页码: 31-34
ISSN:0378-584X
年代: 1991
DOI:10.1159/000216941
出版商: S. Karger GmbH
关键词: Breast Cancer;Idarubicin;Monotherapy;First line chemotherapy;Favorable prognosis
数据来源: Karger
摘要:
Idarubicin is a new anthracycline derivative with therapeutic efficacy in metastatic breast cancer. In a phase II trial we treated 23 patients with advanced breast carcinoma and favourable prognostic factors. Oral dose of idarubicin was 15 mg/m2 day 1–3 repeated every 3 weeks. All patients were pre treated with hormones. Idarubicin was administered as first line chemotherapy. 20 patients were evaluable for response: 3 patients achieved partial remission, 12 patients stable disease; tumour progression occurred in 5 patients. 3 patients were not evaluable for response because only 1 treatment cycle was administered. Main toxicites were leukopenia (median WHO-grade: 2, r:0–4), nausea and vomiting (median: l, r:0–4) and alopezia (median: l, r:0–3). 1 patient died in septic shock: Immediately after the administration of one idarubicine cycle, she was extensively irradiated because of bone metastasis. The fatal course of the disease in this patient does not depend only on the idarubicin therapy, but also on the extensive bone infiltration and on intensive radiation therapy. Idarubicin proved to be an effective drug in metastatic breast cancer with low systemic toxicity and the advantage of oral administration. The drug is an enrichment of therapeutic armament, especially in patients with soft tissue and bone met
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