The nuclear factor‐κB/inhibitor of kappa B autoregulatory system and atherosclerosis
作者:
Beth Thurberg,
Tucker Collins,
期刊:
Current Opinion in Lipidology
(OVID Available online 1998)
卷期:
Volume 9,
issue 5
页码: 387-396
ISSN:0957-9672
年代: 1998
出版商: OVID
数据来源: OVID
摘要:
Nuclear factor‐κB is a ubiquitous transcription factor that can be activated by diverse proatherogenic stimuli such as inflammatory cytokines, lipopolysaccharide, oxidant stress and physical forces. Recently, there have been major advances in understanding signal transduction from the tumor necrosis factor receptor, a model activator of the nuclear factor‐κB system. One set of signals from the receptor initiates a phosphorylation cascade resulting in the activation of a kinase complex which phosphorylates an inhibitor of nuclear factor‐κB, or inhibitor of kappa B. Degradation of the inhibitor occurs in parallel with activation and nuclear accumulation of the transcription factor. Subsequent changes in gene expression induce the production of multiple cytokines and adhesion molecules, which are important in early atherosclerotic lesion formation, and generation of survival signals, which could be important in lesion progression. A second set of signals from the tumor necrosis factor receptor leads to cell death. Understanding these competing pathways in vascular cells may help to clarify the role of this transcription factor in the proliferative lesions of atherogenesis. Curr Opin Lipidol 9:387–396. © 1998 Lippincott Williams & Wilkins
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