Small intestinal biopsy in children with coeliac disease: measurement of radiation dose and analysis of risk
作者:
J Persliden,
HBL Pettersson,
K Fälth‐Magnusson,
期刊:
Acta Pædiatrica
(WILEY Available online 1993)
卷期:
Volume 82,
issue 3
页码: 296-299
ISSN:0803-5253
年代: 1993
DOI:10.1111/j.1651-2227.1993.tb12663.x
出版商: Blackwell Publishing Ltd
关键词: Children;coeliac disease;fluoroscopy;radintion dose;radiation risk;small intestinal biopsy
数据来源: WILEY
摘要:
To verify the diagnosis of coeliac disease in childhood, three consecutive small intestinal biopsies are performed under fluoroscopic control. To assess the amount of radiation dose absorbed during biopsy, dose measurements were performed both in patients and in a phantom model. These measurements were used for a theoretical assessment of cancer risk and shortening of life due to radiation exposure. The cancer excess lifetime mortality risk (CELMR) was 0.001, i.e. 1 case per 1000 children with a diagnosis of coeliac disease. The loss of life expectancy after three small intestinal biopsies in childhood was approximately 15% of the risk due to lifetime exposure to natural background radiation. These results should be compared with the reported increased risk of malignancy for undiagnosed coeliac disease in adult age. Although the exccss risk of the biopsies was small, all efforts should be made to use a technique and equipment giving the least radiation dose.
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