Influence of Acute Estrogenic Withdrawal on Blood Calcitonin
作者:
F. Pansini,
S. Bettocchi, Jr.,
C. Bergamini,
A. Bianchi,
R. Ambrosecchia,
B. Bagni,
G. Mollica,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1984)
卷期:
Volume 18,
issue 1
页码: 21-26
ISSN:0378-7346
年代: 1984
DOI:10.1159/000299043
出版商: S. Karger AG
关键词: Calcitonin;Oophorectomy;Postmenopausal osteoporosis
数据来源: Karger
摘要:
As a model to investigate the pathogenesis of postmenopausal osteoporosis and the involvement of calcitonin in the bone alterations, we chose surgical menopause, studying the influence of castration on blood calcitonin. After surgery, the hormone and calcemia were raised significantly over preoperative values in castrated women, but not so in a control group of patients undergoing hysterectomy without oophorectomy. The elevated concentration of calcitonin was maintained during at least 4 months. It is speculated that this mechanism of control of calcitonin secretion by gonadal hormones might be activated in the pathogenesis of postmenopausal osteoporosis.
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