A New Staurosporine Analog from the Prosobranch MolluskCoriocella Nigra
作者:
CharlesL. Cantrell,
Amiram Groweiss,
KirkR. Gustafson,
MichaelR. Boyd,
期刊:
Natural Product Letters
(Taylor Available online 1999)
卷期:
Volume 14,
issue 1
页码: 39-46
ISSN:1057-5634
年代: 1999
DOI:10.1080/10575639908045433
出版商: Taylor & Francis Group
关键词: Coriocella nigra;Coriocella hibyae;staurosporine;prosobranch mollusk
数据来源: Taylor
摘要:
A new staurosporine analog, 4′-N-demethyl-11-hydroxystaurosporine (1), has been isolated by cytotoxicity-guided fractionation of an organic extract of the prosobranch molluskCoriocella nigra. The known staurosporine derivative 3,11-dihydroxystaurosporine (2) was also isolated from this extract. Concurrent investigations ofCoriocella hibyaeresulted in the isolation of two known compounds, lamellarins C (3) and U (4). The structures of1, 2, 3 and 4were elucidated by spectroscopic methods and the compounds were evaluated for cytotoxicity against 10 human tumor cell lines. Compounds1and2demonstrated potent cytotoxic activity with IC50's ranging from approximately 2 to 66 ng/mL.
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